Zhang Yizhuo, Li Dan, Lu Shaohong, Zheng Bin
Institute of Parasitic Diseases, School of Basic Medicine and Forensics, Hangzhou Medical College, Hangzhou, China.
Engineering Research Center of Novel Vaccine of Zhejiang Province, Hangzhou Medical College, Hangzhou, China.
NPJ Vaccines. 2022 Oct 31;7(1):131. doi: 10.1038/s41541-022-00563-0.
Despite recent major advances in developing effective vaccines against toxoplasmosis, finding new protective vaccination strategies remains a challenging and elusive goal as it is critical to prevent the disease. Over the past few years, various experimental approaches have shown that developing an effective vaccine against T. gondii is achievable. However, more remains unknown due to its complicated life cycle, difficulties in clinical translation, and lack of a standardized platform. This minireview summarizes the recent advances in the development of T. gondii vaccines and the main obstacles to developing a safe, effective and durable T. gondii vaccine. The successes and failures in developing and testing vaccine candidates for the T. gondii vaccine are also discussed, which may facilitate the future development of T. gondii vaccines.
尽管近年来在开发有效的抗弓形虫疫苗方面取得了重大进展，但寻找新的保护性疫苗接种策略仍然是一个具有挑战性且难以实现的目标，因为预防该疾病至关重要。在过去几年中，各种实验方法表明，开发一种有效的抗弓形虫疫苗是可以实现的。然而，由于其复杂的生命周期、临床转化困难以及缺乏标准化平台，仍有许多未知之处。本综述总结了抗弓形虫疫苗开发的最新进展以及开发安全、有效和持久的抗弓形虫疫苗的主要障碍。还讨论了抗弓形虫疫苗候选物开发和测试中的成功与失败，这可能有助于抗弓形虫疫苗的未来发展。
