Zeng Xiaoqin, Li Jingda, Yang Fuyuan, Xia Rui
Department of Anaesthesiology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
College of Life Sciences, Yangtze University, Jingzhou, Hubei, China.
Front Pharmacol. 2022 Oct 13;13:1020447. doi: 10.3389/fphar.2022.1020447. eCollection 2022.
Ferroptosis is a novel programmed cell death form characterized by iron-mediated reactive oxygen species-induced lipid peroxidation and subsequent cell damage that is distinct from apoptosis, necroptosis, pyroptosis, and autophagy. Most studies on ferroptosis are based on its function and mechanism, but there have been relatively few studies on the effects of drugs, especially anaesthetics, on ferroptosis. Therefore, we summarized the recent literature on the effects of anaesthetics on ferroptosis to understand the underlying mechanism. In particular, we focused on the targets of various anaesthetics in different mechanisms of ferroptosis and the effects of ferroptosis induction or inhibition by narcotics on various diseases. The aims of this review are to provide a relatively reasonable drug regimen for clinicians, to explore potential ferroptosis protection drugs and targets, to reduce perioperative complications and to improve the postoperative performance of patients, especially those who are critically ill.
铁死亡是一种新型的程序性细胞死亡形式，其特征是铁介导的活性氧诱导的脂质过氧化以及随后的细胞损伤，这与凋亡、坏死性凋亡、焦亡和自噬不同。大多数关于铁死亡的研究基于其功能和机制，但关于药物，尤其是麻醉药对铁死亡影响的研究相对较少。因此，我们总结了近期关于麻醉药对铁死亡影响的文献，以了解其潜在机制。特别是，我们关注了各种麻醉药在铁死亡不同机制中的靶点，以及麻醉药诱导或抑制铁死亡对各种疾病的影响。本综述的目的是为临床医生提供相对合理的用药方案，探索潜在的铁死亡保护药物和靶点，减少围手术期并发症，改善患者，尤其是重症患者的术后表现。
