Seyedin Steven N, Bassalow Rostem, Mawlawi Osama R, Turner Lehendrick M, Patel Roshal R, Mazin Samuel R, Oderinde Oluwaseyi M, Voronenko Yevgen, Wages Cody A, Olcott Peter D, Chang Joe Y, Balter Peter A, Welsh James W
Department of Radiation Oncology, University of California, Irvine-Chao Family Comprehensive Cancer Center, Orange, CA, United States.
Northwest Medical Physics Center, Lynnwood, WA, United States.
Front Oncol. 2022 Oct 14;12:921473. doi: 10.3389/fonc.2022.921473. eCollection 2022.
We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.
Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions).
For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT.
BgRT has the potential to reduce the radiation dose to proximal critical structures but requires further detailed investigation.
我们研究了生物引导放射治疗（BgRT）的可行性，该技术利用实时正电子发射成像来最小化肿瘤运动的不确定性，以保护附近的危及器官。
为气管旁淋巴结复发（病例1；10次分割，60 Gy）和原发性左肺上叶周围腺癌（病例2；4次分割，50 Gy）制定了容积调强弧形治疗（VMAT）、调强质子治疗（IMPT）和BgRT计划。
对于病例1，与VMAT和IMPT相比，BgRT产生的支气管V40值更低。对于病例2，与VMAT和IMPT相比，BgRT病例的全肺V20更低。
BgRT有可能降低对近端关键结构的辐射剂量，但需要进一步详细研究。
