Takahashi H, Yamana K, Maeda K, Akutsu Y, Horikoshi T, Jimbow K
Am J Dermatopathol. 1987 Jun;9(3):189-97. doi: 10.1097/00000372-198706000-00002.
Dysplastic melanocytic nevi (DMN) are distinctive cutaneous nevomelanocytic lesions that possess unique clinical and histopathological features. In our previous study, we showed that the fine structure of melanosomes in epidermal melanocytes of DMN are abnormal and reveal deranged melanogenesis. This study is an extension of our previous study and clarifies the fine structure of melanosomes in both epidermal melanocytes and keratinocytes with observations in an additional 10 cases of DMN with and without a marked mesenchymal response. We found that a poor mesenchymal response does not exclude fine structural abnormality of melanosomes in DMN; that abnormal melanosomes are manifested by a spherical shape with either fine granules or incompletely developed lamellae and/or both; that melanization occurs unevenly on the spherical granular and/or incompletely on the lamellar matrices; and that these abnormal melanosomes are transferred to keratinocytes before being completely melanized, and they reveal marked degradation. We suggest that the fine structural characterization of abnormal melanosomes is a new adjunct for histopathological diagnosis of DMN.
发育异常性黑素细胞痣（DMN）是具有独特临床和组织病理学特征的特殊皮肤黑素细胞性病变。在我们之前的研究中，我们表明DMN表皮黑素细胞中黑素小体的精细结构异常，并揭示了黑素生成紊乱。本研究是我们之前研究的延伸，通过对另外10例有或无明显间充质反应的DMN进行观察，阐明了表皮黑素细胞和角质形成细胞中黑素小体的精细结构。我们发现，间充质反应不佳并不排除DMN中黑素小体的精细结构异常；异常黑素小体表现为球形，带有细颗粒或发育不完全的板层和/或两者皆有；黑素化在球形颗粒上不均匀发生和/或在板层基质上不完全发生；并且这些异常黑素小体在完全黑素化之前转移到角质形成细胞中，并显示出明显的降解。我们认为，异常黑素小体的精细结构特征是DMN组织病理学诊断的一种新辅助手段。
