Fu Meimei, Zhao Yitao, Wang Yue, Li Yue, Wu Min, Liu Qi, Hou Zhiguo, Lu Zhihui, Wu Keke, Guo Jinshan
Department of Histology and Embryology, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510515, P. R. China.
Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, P. R. China.
Small. 2023 Jan;19(3):e2205489. doi: 10.1002/smll.202205489. Epub 2022 Nov 1.
Current diabetic wound treatments remain unsatisfactory due to the lack of a comprehensive strategy that can integrate strong applicability (tissue adhesiveness, shape adaptability, fast self-healability, and facile dressing change) with the initiation and smooth connection of the cascade wound healing processes. Herein, benefiting from the multifaceted bonding ability of tannic acid to metal ions and various polymers, a family of tannin-europium coordination complex crosslinked citrate-based mussel-inspired bioadhesives (TE-CMBAs) are specially developed for diabetic wound healing. TE-CMBAs can gel instantly (< 60 s), possess favorable shape-adaptability, considerable mechanical strengths, high elasticity, considerable wet tissue adhesiveness (≈40 kPa), favorable photothermal antimicrobial activity, excellent anti-oxidant activity, biocompatibility, and angiogenetic property. The reversible hydrogen bond crosslinking and sensitive metal-phenolic coordination also confers TE-CMBAs with self-healability, pH-responsive europium ion and TA releasing properties and on-demand removability upon mixing with borax solution, enabling convenient painless dressing change and the smooth connection of inflammatory microenvironment modulation, angiogenesis promotion, and effective extracellular matrix production leveraging the acidic pH condition of diabetic wounds. This adhesive dressing provides a comprehensive regenerative strategy for diabetic wound management and can be extended to other complicated tissue healing scenarios.
由于缺乏一种能将强大的适用性（组织粘附性、形状适应性、快速自愈性和便捷的换药）与级联伤口愈合过程的启动和平滑连接相结合的综合策略，目前的糖尿病伤口治疗方法仍不尽人意。在此，受益于单宁酸与金属离子和各种聚合物的多方面结合能力，专门开发了一类单宁 - 铕配位络合物交联的基于柠檬酸盐的贻贝启发型生物粘合剂（TE-CMBA）用于糖尿病伤口愈合。TE-CMBA 能在瞬间（<60 秒）凝胶化，具有良好的形状适应性、相当的机械强度、高弹性、可观的湿组织粘附性（≈40 kPa）、良好的光热抗菌活性、优异的抗氧化活性、生物相容性和促血管生成特性。可逆的氢键交联和灵敏的金属 - 酚配位还赋予 TE-CMBA 自愈性、pH 响应性铕离子和单宁酸释放特性以及与硼砂溶液混合时的按需可去除性，从而实现便捷无痛的换药，并利用糖尿病伤口的酸性 pH 条件实现炎症微环境调节、血管生成促进和有效细胞外基质产生的平滑连接。这种粘性敷料为糖尿病伤口管理提供了一种综合的再生策略，并且可以扩展到其他复杂的组织愈合场景。
