Brown Michael, Saund Jasjot, Qureshi Azka, Plowright Megan, Drury Katie, Gahir Joshua, Simpson Tom, Newman Thomas, Adams Kate, Galloway James, Durairaj Kezia, Elgizouli Kamla, Rampling Tommy, Cole Joby, Easom Nicholas, Goodman Anna L, Marks Michael
Division of Infection, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Open Forum Infect Dis. 2022 Oct 6;9(10):ofac527. doi: 10.1093/ofid/ofac527. eCollection 2022 Oct.
COVID-19 medicines delivery units (CMDU) were established in late December 2021 to deliver early antiviral therapy to patients classified as at risk with the aim of preventing hospitalization.
We performed a service evaluation at 4 CMDUs in England. We assessed demographics and triage outcomes of CMDU referral, uptake of antiviral therapy, and the rate of subsequent hospitalizations within 2 weeks of CMDU referral.
Over a 3-week period, 4788 patients were referred and 3989 were ultimately assessed by a CMDU. Overall, 832 of the patients referred (17%) were judged eligible for treatment and 628 (13%) were ultimately prescribed an antiviral agent. The overall rate of admission within 14 days was 1%. Patients who were admitted were significantly older than those who did not require hospitalization. Of patients prescribed molnupiravir and sotrovimab, 1.8% and 3.2%, respectively, were admitted.
There was a high volume of referrals to CMDU service during the initial surge of the Omicron wave in the United Kingdom. A minority of patients were judged to be eligible for therapy. In a highly vaccinated population, the overall hospitalization rate was low.
2021年12月下旬设立了新冠病毒-19药物配送单位（CMDU），为被归类为高危的患者提供早期抗病毒治疗，以防止住院。
我们在英国的4个CMDU进行了服务评估。我们评估了CMDU转诊的人口统计学和分诊结果、抗病毒治疗的接受情况以及CMDU转诊后2周内的后续住院率。
在3周的时间里，有4788名患者被转诊，最终有3989名患者由CMDU进行了评估。总体而言，被转诊的患者中有832名（17%）被判定符合治疗条件，628名（13%）最终被开具了抗病毒药物。14天内的总体住院率为1%。入院的患者明显比那些不需要住院的患者年龄大。在开具莫努匹韦和索托维单抗的患者中，分别有1.8%和3.2%的患者入院。
在英国奥密克戎毒株浪潮初期，CMDU服务的转诊量很大。少数患者被判定符合治疗条件。在疫苗接种率很高的人群中，总体住院率较低。
