The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.
London School of Hygiene and Tropical Medicine, London.
Br J Gen Pract. 2021 Dec 31;72(714):e51-e62. doi: 10.3399/BJGP.2021.0376. Print 2022 Jan.
On 8 December 2020 NHS England administered the first COVID-19 vaccination.
To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout.
With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY.
Vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts is described.
A total of 20 852 692 patients (36.0%) received a vaccine between 8 December 2020 and 17 March 2021. Of patients aged ≥80 years not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2%, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5%) and learning disability (91.4%). There were 275 205 vaccine recipients who were identified as care home residents (JCVI group 1; 91.2% coverage). By 17 March, 1 257 914 (6.0%) recipients had a second dose.
The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups.
2020 年 12 月 8 日，英国国家医疗服务体系（NHS）开始接种第一剂 COVID-19 疫苗。
描述疫苗接种计划实施的前 100 天中，不同临床和人群组的疫苗接种覆盖率的趋势和变化。
在获得英国国家医疗服务体系的批准后，我们对英格兰普通诊所的 5790 万患者记录进行了一项队列研究，使用 OpenSAFELY 并通过 EMIS 和 TPP 的电子健康记录软件供应商基础设施进行。
描述了联合疫苗接种和免疫委员会（JCVI）优先群体的各个亚组的疫苗接种情况。
共有 20852692 名患者（36.0%）在 2020 年 12 月 8 日至 2021 年 3 月 17 日期间接种了疫苗。在未入住养老院的 80 岁及以上人群（JCVI 组 2）中，94.7%的人接种了疫苗，但族裔（白人 96.2%，黑人 68.3%）和贫困程度（最不贫困 96.6%，最贫困 90.7%）存在显著差异。患有预先存在的医疗条件的患者更有可能接种疫苗，但有两个例外：严重精神疾病（89.5%）和学习障碍（91.4%）。有 275205 名疫苗接种者被确定为养老院居民（JCVI 组 1；覆盖率为 91.2%）。截至 3 月 17 日，有 1257914 人（6.0%）接受了第二剂。
NHS 迅速开展了大规模疫苗接种工作。在这项研究中，使用公开可审计的方法和安全的处理模型部署了数据监测框架，使用链接但匿名化的 NHS 患者级数据对 5790 万名患者进行了研究。可能需要采取有针对性的活动来解决某些关键群体中观察到的较低的疫苗接种率。
