Novikov D K, Novikova V I, Gorbach A D, Pchel'nikov Iu V
Zh Mikrobiol Epidemiol Immunobiol. 1978 Apr(4):55-9.
A factor suppressing the migration of donor leukocytes and macrophages of guinea pigs in vitro was revealed in the blood serum of patients suffering from chronic inflammatory diseases (pneumonia, rheumatism, tuberculosis) and carcinoma. A factor stimulating the leukocyte migration was sometimes revealed in the blood sera of the patients. In chromatography of the blood sera on sephadex G-100 the activity of both factors proved to localize in fractions with the mol wt of 15000--45000 dalton. Depression of stimulation of leukocyte migration could be also caused by immunoglobulin fractions (mol wt--150000 dalton) of the blood sera of patients suffering from acute pneumonia, apparently on account of the presence in them of the antigen-antibody complex; however, these sera contained no migration suppression factor. The blood serum fractions with the mol wt of 15000--45000 dalton, including those containing the migration suppression factor inhibited the inhibited the spontaneous and induced by phytohemagglutinin blast transformation lymphocytes, and the immunoglobulin ones--the latter only. Apparently the migration suppression factor of the blood serum served as the product of activated lymphocytes.
在患有慢性炎症性疾病（肺炎、风湿、结核）和癌症的患者血清中，发现了一种能在体外抑制豚鼠供体白细胞和巨噬细胞迁移的因子。有时在这些患者的血清中也发现了一种刺激白细胞迁移的因子。在葡聚糖凝胶G - 100上对血清进行层析时，这两种因子的活性均定位于分子量为15000 - 45000道尔顿的组分中。急性肺炎患者血清中的免疫球蛋白组分（分子量 - 150000道尔顿）显然由于其中存在抗原 - 抗体复合物，也可能导致白细胞迁移刺激的抑制；然而，这些血清中不含迁移抑制因子。分子量为15000 - 45000道尔顿的血清组分，包括那些含有迁移抑制因子的组分，抑制了自发的以及由植物血凝素诱导的淋巴细胞母细胞转化，而免疫球蛋白组分仅抑制后者。显然，血清中的迁移抑制因子是活化淋巴细胞的产物。
