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青年起病型结肠癌:一例报告

Young-Onset Colon Cancer: A Case Report.

作者信息

Hashmi Syed Salman Hamid, Shady Ahmed, Atallah-Vinograd Jean, Cummings Donelle, Maranino Ashley, Harley Jennifer

机构信息

Internal Medicine, NYU (New York University) Langone, Woodhull Medical Center, New York City, USA.

Gastroenterology, New York Medical College, Metropolitan Hospital Center, New York City, USA.

出版信息

Cureus. 2022 Sep 27;14(9):e29667. doi: 10.7759/cureus.29667. eCollection 2022 Sep.

DOI:10.7759/cureus.29667
PMID:36320989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9613351/
Abstract

Colorectal cancer (CRC) which is diagnosed in patients under the age of 50 years is defined as young-onset CRC. There has been a substantial increase in the incidence and mortality of young-onset CRC in the past four decades and the patients have delayed diagnoses leading to the advanced stages of CRC at the time of diagnosis. Here we present a case of a 34-year-old male patient with colon cancer and a literature review on young-onset colon cancer to highlight the age-related disparities in CRC incidence and try to explore the possible causative factors for the rise in incidence and mortality in young patients due to CRC.

摘要

50岁以下患者被诊断出的结直肠癌(CRC)被定义为青年型结直肠癌。在过去四十年中,青年型结直肠癌的发病率和死亡率大幅上升,且患者诊断延迟,导致诊断时已处于结直肠癌晚期。在此,我们展示一例34岁结肠癌男性患者的病例,并对青年型结肠癌进行文献综述,以突出结直肠癌发病率与年龄相关的差异,并试图探讨青年患者因结直肠癌导致发病率和死亡率上升的可能致病因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/719e08679d3f/cureus-0014-00000029667-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/48c421e8caa2/cureus-0014-00000029667-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/3d72f1097bd9/cureus-0014-00000029667-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/33f5c063ca0c/cureus-0014-00000029667-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/8f8f8a31ab94/cureus-0014-00000029667-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/719e08679d3f/cureus-0014-00000029667-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/48c421e8caa2/cureus-0014-00000029667-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/3d72f1097bd9/cureus-0014-00000029667-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/33f5c063ca0c/cureus-0014-00000029667-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/8f8f8a31ab94/cureus-0014-00000029667-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67d7/9613351/719e08679d3f/cureus-0014-00000029667-i05.jpg

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本文引用的文献

1
Young-onset colorectal cancer: A review.青年期结直肠癌:综述
World J Gastrointest Oncol. 2021 Aug 15;13(8):856-866. doi: 10.4251/wjgo.v13.i8.856.
2
NCCN Guidelines Insights: Rectal Cancer, Version 6.2020.NCCN 指南解读:直肠癌,第 6 版,2020 年。
J Natl Compr Canc Netw. 2020 Jul;18(7):806-815. doi: 10.6004/jnccn.2020.0032.
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Epidemiology of Colorectal Cancer in Average Risk Adults 20-39 Years of Age: A Population-Based National Study.20-39 岁普通风险成年人结直肠癌的流行病学:一项基于人群的全国性研究。
Dig Dis Sci. 2019 Dec;64(12):3602-3609. doi: 10.1007/s10620-019-05690-8. Epub 2019 Jun 7.
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Colorectal Cancer in the Young: Does Screening Make Sense?年轻人的结直肠癌:筛查有意义吗?
Curr Gastroenterol Rep. 2019 May 16;21(7):28. doi: 10.1007/s11894-019-0695-4.
5
Clinical and molecular characterization of early-onset colorectal cancer.早发性结直肠癌的临床和分子特征。
Cancer. 2019 Jun 15;125(12):2002-2010. doi: 10.1002/cncr.31994. Epub 2019 Mar 11.
6
Colorectal Cancer Presentation and Survival in Young Individuals: A Retrospective Cohort Study.青年个体的结直肠癌表现与生存情况:一项回顾性队列研究。
Cancers (Basel). 2018 Nov 28;10(12):472. doi: 10.3390/cancers10120472.
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Decrease in Incidence of Young-Onset Colorectal Cancer Before Recent Increase.青年发病型结直肠癌发病率近期上升前的下降趋势。
Gastroenterology. 2018 Dec;155(6):1716-1719.e4. doi: 10.1053/j.gastro.2018.07.045. Epub 2018 Aug 27.
8
Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014.加利福尼亚州 1990-2014 年按年龄、分期和种族/族裔划分的结直肠癌发病率趋势
Cancer Epidemiol Biomarkers Prev. 2018 Sep;27(9):1011-1018. doi: 10.1158/1055-9965.EPI-18-0030. Epub 2018 Aug 16.
9
Prevalence of and Risk Factors for Colorectal Neoplasia in Asymptomatic Young Adults (20-39 Years Old).无症状年轻成年人(20-39 岁)结直肠肿瘤的流行率和危险因素。
Clin Gastroenterol Hepatol. 2019 Jan;17(1):115-122. doi: 10.1016/j.cgh.2018.07.011. Epub 2018 Jul 17.
10
Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society.美国癌症协会 2018 年普通风险成年人结直肠癌筛查指南更新
CA Cancer J Clin. 2018 Jul;68(4):250-281. doi: 10.3322/caac.21457. Epub 2018 May 30.