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儿童择期大肠手术的甲硝唑预防:一项前瞻性试验。

Metronidazole prophylaxis for elective large bowel surgery in children: a prospective trial.

作者信息

Khan O, Nixon H H

出版信息

Br J Surg. 1978 Nov;65(11):804-7. doi: 10.1002/bjs.1800651112.

DOI:10.1002/bjs.1800651112
PMID:363217
Abstract

In a controlled trial in children aged 2 days to 16 years undergoing large bowel surgery a group of 15 patients had preoperative mechanical bowel preparation and oral neomycin while a second group of 15 patients was similarly prepared but also had preoperative and postoperative metronidazole medication. Five of the 9 postoperative infections in the first group involved Bacteroides spp. but no anaerobe was found in the 3 wound infections in the metronidazole group.

摘要

在一项针对年龄在2天至16岁接受大肠手术儿童的对照试验中,一组15名患者进行了术前机械肠道准备并口服新霉素,而另一组15名患者进行了类似的准备,但术前和术后还接受了甲硝唑治疗。第一组9例术后感染中有5例涉及拟杆菌属,但甲硝唑组的3例伤口感染中未发现厌氧菌。

相似文献

1
Metronidazole prophylaxis for elective large bowel surgery in children: a prospective trial.儿童择期大肠手术的甲硝唑预防:一项前瞻性试验。
Br J Surg. 1978 Nov;65(11):804-7. doi: 10.1002/bjs.1800651112.
2
The effect of metronidazole on the incidence of postoperative wound infection in elective colon surgery.
Am J Surg. 1978 Jan;135(1):91-6. doi: 10.1016/0002-9610(78)90016-8.
3
Antibiotic prophylaxis in large bowel surgery: results of a controlled clinical trial.大肠手术中的抗生素预防:一项对照临床试验的结果
Surgery. 1983 Jan;93(1 Pt 2):190-6.
4
Randomized multicentre trial of oral bowel preparation and antimicrobials for elective colorectal operations.
Br J Surg. 1978 Sep;65(9):597-600. doi: 10.1002/bjs.1800650902.
5
Metronidazole as a prophylactic agent in wound infection after colon surgery.甲硝唑作为结肠手术后伤口感染的预防药物。
Surgery. 1983 Jan;93(1 Pt 2):197-200.
6
Importance of adding neomycin to metronidazole for bowel preparation.在肠道准备中,将新霉素添加到甲硝唑中的重要性。
J R Soc Med. 1980 Apr;73(4):238-40. doi: 10.1177/014107688007300405.
7
A randomized evaluation of single dose chemoprophylaxis in elective colorectal surgery--a comparison between metronidazole and doxycycline.择期结直肠手术中单剂量化学预防的随机评估——甲硝唑与多西环素的比较
Ann Clin Res. 1983;15(1):15-20.
8
[Wound infection prophylaxis in colonic and rectal surgery with metronidazole and neomycin--a prospective study].[甲硝唑和新霉素用于结肠直肠手术伤口感染预防的前瞻性研究]
Zentralbl Chir. 1982;107(13):763-7.
9
Is neomycin necessary for bowel preparation in surgery of the colon? Oral neomycin plus erythromycin versus erythromycin-metronidazole.结肠手术中肠道准备有必要使用新霉素吗?口服新霉素加红霉素与红霉素-甲硝唑对比。
Can J Surg. 1989 Jul;32(4):265-70.
10
[Metronidazole and neomycin in wound infection prophylaxis in colon and rectal surgery].[甲硝唑与新霉素在结肠直肠手术伤口感染预防中的应用]
Nahrung. 1984;28(6-7):685-7. doi: 10.1002/food.19840280642.

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1
Disposition kinetics of metronidazole in children.
Eur J Clin Pharmacol. 1983;24(1):113-9. doi: 10.1007/BF00613937.