Vallance S, Jones B, Arabi Y, Keighley M R
J R Soc Med. 1980 Apr;73(4):238-40. doi: 10.1177/014107688007300405.
A prospective randomized trial has investigated whether it is necessary to add oral neomycin to oral metronidazole as a means of preventing sepsis in elective colonic resection. Seventy-three patients completed the study; 41 received metronidazole and placebo neomycin and 32 received metronidazole and active neomycin. There was a significant reduction in the incidence of wound infection in patients receiving neomycin and metronidazole (22%) compared with metronidazole alone (51%, P<0.02). There was also a significant reduction in anaerobic infections in the group receiving metronidazole and neomycin compared with metronidazole alone (P<0.05). These results indicate that oral metronidazole alone is of no benefit for patients requiring elective colonic operations and that if oral metronidazole is advised it should always be given in combination with oral neomycin.
一项前瞻性随机试验研究了在择期结肠切除术中，是否有必要在口服甲硝唑的基础上加用口服新霉素以预防败血症。73名患者完成了该研究；41名患者接受了甲硝唑和安慰剂新霉素治疗，32名患者接受了甲硝唑和活性新霉素治疗。与仅接受甲硝唑治疗的患者相比，接受新霉素和甲硝唑治疗的患者伤口感染发生率显著降低（22%对比51%，P<0.02）。与仅接受甲硝唑治疗的组相比，接受甲硝唑和新霉素治疗的组厌氧感染也显著减少（P<0.05）。这些结果表明，对于需要进行择期结肠手术的患者，仅口服甲硝唑并无益处，并且如果建议使用口服甲硝唑，应始终与口服新霉素联合使用。
