Hinchey E J, Richards G K, Prentis J
Surgery. 1983 Jan;93(1 Pt 2):197-200.
Metronidazole was the most effective antianaerobic agent tested in an in vitro system that used a high-density inoculum of mixed enteric organisms. A prospective randomized clinical trial assessing metronidazole and neomycin against erythromycin and neomycin as preoperative bowel preparations demonstrated a marked reduction in the anaerobic flora of patients receiving metronidazole. A second trial revealed that intravenous metronidazole administered 1 hour before and at 8 and 16 hours after the operation provided similar protection against wound infection. Our total experience with 181 patients receiving metronidazole either by mouth or intravenously was three wound infections caused by aerobic enteric organisms, as incidence of 1.6%. There was no wound infection owing to anaerobic organisms of gut origin. The residual problem was that of six wound infections resulting from Staphylococcus aureus presumed to be of skin origin.
在一个使用高密度混合肠道菌群接种物的体外系统中，甲硝唑是所测试的最有效的抗厌氧菌药物。一项前瞻性随机临床试验评估了甲硝唑和新霉素与红霉素和新霉素作为术前肠道准备的效果，结果表明接受甲硝唑治疗的患者厌氧菌群显著减少。第二项试验显示，在手术前1小时以及术后8小时和16小时静脉注射甲硝唑，对预防伤口感染具有相似的保护作用。我们对181例口服或静脉使用甲硝唑的患者的总体经验是，有3例伤口感染由需氧肠道菌引起，发生率为1.6%。没有因肠道来源的厌氧菌导致的伤口感染。遗留的问题是有6例伤口感染是由推测为皮肤来源的金黄色葡萄球菌引起的。
