Reynolds N C, Montgomery G K
Arch Neurol. 1987 Oct;44(10):1013-6. doi: 10.1001/archneur.1987.00520220019009.
The question of how pathophysiologic mechanisms may combine to yield significant performance impairment in Parkinson's disease was studied by factor analysis of the covariation among behavioral deficits observed during simulated daily living activities. Eighty-four patients with idiopathic Parkinson's disease were videotape-recorded while performing a sequence of nine common tasks of daily living in a standardized format. Acceptable observer reliability was achieved for ten clinical signs that were factor-analyzed to suggest three dimensions of motor performance: ambulation, tremor, and animation. The findings are discussed with respect to traditional concepts of Parkinson's disease and the possible interplay between primary disease mechanisms.
通过对模拟日常生活活动中观察到的行为缺陷之间的协变进行因素分析，研究了病理生理机制如何结合导致帕金森病患者出现显著的功能障碍。对84例特发性帕金森病患者进行录像，他们以标准化形式执行一系列九项常见的日常任务。对十个临床体征进行因素分析，以提示运动功能的三个维度：行走、震颤和活动度，观察者间的可靠性良好。结合帕金森病的传统概念以及主要疾病机制之间可能的相互作用对研究结果进行了讨论。
