Hyun Jung Hee, Yoon Ju Young, Lee Sang Hyuk
Division of Healthcare Associated Infection Control, Bureau of Healthcare Safety and Immunization, Korea Disease Control and Prevention Agency, Cheongju, Korea.
College of Nursing, Seoul National University, Seoul, Korea.
Osong Public Health Res Perspect. 2022 Oct;13(5):352-359. doi: 10.24171/j.phrp.2022.0141. Epub 2022 Oct 12.
We aimed to reconfirm the source of hepatitis A virus (HAV) infection through epidemiological and genotype investigations of individual cases in a 2019 outbreak in South Korea.
We investigated food intake histories, associations with hepatitis A, and genotypes of HAV in 31 patients with hepatitis aged 20 to 49 years registered in the integrated disease and health management system during December 1-7, 2019 (case group) and in 35 sex- and agematched people without a history of HAV vaccination or infection among patients' families and colleagues (control group).
The consumption of salted clams was a significant factor (odds ratio, 4.33; 95% confidence interval, 1.32-14.18) in the risk factor analysis of food intake history. HAV genotypes were analyzed in 24 of 31 patients. Type IA and type IIIA were found in 23 and 1 cases, respectively.
Salted clams are considered to have been the source of HAV infection at 49 weeks of the HAV outbreak in 2019; this result was consistent with that of a previous epidemiological investigation conducted by the Korea Disease Control and Prevention Agency in September 2019. Therefore, monitoring of the production and distribution of salted clams needs to be continued.
我们旨在通过对2019年韩国一次甲型肝炎病毒（HAV）暴发中个别病例进行流行病学和基因型调查，重新确认HAV感染源。
我们调查了2019年12月1日至7日在综合疾病与健康管理系统中登记的31例20至49岁肝炎患者（病例组）以及患者家属和同事中35名年龄和性别匹配且无HAV疫苗接种或感染史的人（对照组）的食物摄入史、与甲型肝炎的关联以及HAV基因型。
在食物摄入史的危险因素分析中，食用咸蚬是一个显著因素（比值比，4.33；95%置信区间，1.32 - 14.18）。对31例患者中的24例进行了HAV基因型分析。分别在23例和1例中发现了IA型和IIIA型。
咸蚬被认为是2019年HAV暴发第49周时HAV感染源；这一结果与韩国疾病控制与预防机构在2019年9月进行的先前流行病学调查结果一致。因此，需要继续监测咸蚬的生产和分销情况。
