Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.
Biomed Res Int. 2022 Oct 25;2022:8862278. doi: 10.1155/2022/8862278. eCollection 2022.
Bone remodels via resorption and formation, two phenomena that continuously occur in bone turnover. The RANKL/RANK/OPG pathway is one of the several mechanisms that affect bone turnover. The RANKL/OPG ratio has a substantial role in bone resorption. An imbalance between formation and resorption is related to an increased RANKL/OPG balance. OPG, a member of this system, can bind to RANKL and suppress RANK-RANKL interaction, and subsequently, inhibit further osteoclastogenesis. The serum levels of RANKL and OPG in the bone microenvironment are vital for osteoclasts formation. The RANK/RANKL/OPG system plays a role in the pathogenesis of bone disorders. This system can be considered a new treatment target for bone disorders. Soy isoflavones affect the RANK/RANKL/OPG system through numerous mechanisms. Soy isoflavones decrease RANKL levels and increase OPG levels. Therefore, isoflavones improve bone metabolism and decrease bone resorption. Soy isoflavones decrease serum markers of bone resorption and improve bone metabolism. However, while the available data are promising, the results of several studies reported no change in RANKL and OPG levels with isoflavones supplementation. In this regard, current evidence is insufficient for conclusive approval of the efficacy of isoflavones on RANKL/RANK/OPG and further research, including animal and human studies, are needed to confirm the effect of soy isoflavones on the RANKL/RANK/OPG pathway. This study was a review of available evidence to determine the role of isoflavones in bone hemostasis and the RANK/RANKL/OPG pathway. The identification of the effects of isoflavones on the RANKL/RANK/OPG pathway directs future studies and leads to the development of effective treatment strategies for bone disorders.
骨骼通过吸收和形成进行重塑，这两个现象在骨转换中持续发生。RANKL/RANK/OPG 通路是影响骨转换的几种机制之一。RANKL/OPG 比值在骨吸收中起着重要作用。形成和吸收之间的不平衡与 RANKL/OPG 平衡的增加有关。OPG 是该系统的一个成员，它可以与 RANKL 结合并抑制 RANK-RANKL 相互作用，从而抑制破骨细胞的进一步生成。骨微环境中 RANKL 和 OPG 的血清水平对破骨细胞的形成至关重要。RANK/RANKL/OPG 系统在骨骼疾病的发病机制中起作用。该系统可以被认为是骨骼疾病的新治疗靶点。大豆异黄酮通过多种机制影响 RANK/RANKL/OPG 系统。大豆异黄酮降低 RANKL 水平并增加 OPG 水平。因此，异黄酮可改善骨代谢并减少骨吸收。大豆异黄酮降低血清骨吸收标志物并改善骨代谢。然而，虽然现有数据很有希望，但几项研究报告补充异黄酮后 RANKL 和 OPG 水平没有变化。在这方面，目前的证据不足以明确批准异黄酮对 RANKL/RANK/OPG 的疗效，需要进一步的研究，包括动物和人体研究，以确认大豆异黄酮对 RANKL/RANK/OPG 通路的影响。本研究综述了现有证据，以确定异黄酮在骨骼止血和 RANK/RANKL/OPG 通路中的作用。确定异黄酮对 RANKL/RANK/OPG 通路的影响指导未来的研究，并为骨骼疾病的有效治疗策略的发展提供指导。
