LncBook 2.0：整合人类长非编码 RNA 与多组学注释。
LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations.
机构信息
National Genomics Data Center & CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
China National Center for Bioinformation, Beijing 100101, China.
出版信息
Nucleic Acids Res. 2023 Jan 6;51(D1):D186-D191. doi: 10.1093/nar/gkac999.
LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been used in a wide range of lncRNA studies across various biological contexts. Here, we present LncBook 2.0 (https://ngdc.cncb.ac.cn/lncbook), with significant updates and enhancements as follows: (i) incorporation of 119 722 new transcripts, 9632 new genes, and gene structure update of 21 305 lncRNAs; (ii) characterization of conservation features of human lncRNA genes across 40 vertebrates; (iii) integration of lncRNA-encoded small proteins; (iv) enrichment of expression and DNA methylation profiles with more biological contexts and (v) identification of lncRNA-protein interactions and improved prediction of lncRNA-miRNA interactions. Collectively, LncBook 2.0 accommodates a high-quality collection of 95 243 lncRNA genes and 323 950 transcripts and incorporates their abundant annotations at different omics levels, thereby enabling users to decipher functional significance of lncRNAs in different biological contexts.
LncBook 是一个综合性的人类长非编码 RNA（lncRNA）资源，已被广泛应用于各种生物背景下的 lncRNA 研究。在这里，我们展示了 LncBook 2.0（https://ngdc.cncb.ac.cn/lncbook），它具有以下显著的更新和增强功能：（i）整合了 119722 个新转录本、9632 个新基因和 21305 个 lncRNA 的基因结构更新；（ii）描述了人类 lncRNA 基因在 40 种脊椎动物中的保守特征；（iii）整合了 lncRNA 编码的小蛋白；（iv）整合了更多生物学背景下的表达和 DNA 甲基化谱；（v）鉴定了 lncRNA-蛋白质相互作用，并改进了 lncRNA-miRNA 相互作用的预测。总之，LncBook 2.0 容纳了 95243 个 lncRNA 基因和 323950 个转录本的高质量集合，并整合了它们在不同组学水平上的丰富注释，从而使用户能够在不同的生物背景下破译 lncRNA 的功能意义。
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