Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Obesity (Silver Spring). 2023 Jan;31(1):150-158. doi: 10.1002/oby.23587. Epub 2022 Nov 5.
Weight regain occurs after medical weight loss via mechanisms of post-weight-loss "metabolic adaptation." The relationship of inflammatory proteins with weight loss/regain was studied to determine a role for inflammation in metabolic adaptation.
Seventy-four proteins central to inflammation and immune regulation (Olink) were analyzed in plasma from up to 490 participants in a trial of medical weight-loss maintenance. Cross-sectional and longitudinal associations of proteins with weight were measured using linear and mixed effects regression models and t testing, with replication in the Framingham Heart Study.
Broad changes in the inflammatory proteome were observed among the study cohort (60% women, 35% African American) with initial weight loss of ≈8 kg from a median 94 kg at study entry (33/74 proteins; 7 increased; 26 decreased), many of which tracked with weight regain of median ≈2 kg over the next 30 months. Ten proteins were associated with different rates of weight regain, some specifying pathways of chemotaxis and innate immune responses. Several of the observed protein associations were also linked to prevalent obesity in the Framingham Heart Study.
Broad changes in the inflammatory proteome track with changes in weight and may identify specific pathways that modify patterns of weight regain.
通过减肥后的“代谢适应”机制，体重在医学减肥后会出现反弹。本研究旨在探讨炎症蛋白与体重减轻/反弹的关系，以确定炎症在代谢适应中的作用。
在一项医学减肥维持试验中，对多达 490 名参与者的血浆进行了 74 种与炎症和免疫调节相关的核心蛋白（Olink）分析。使用线性和混合效应回归模型以及 t 检验测量了蛋白质与体重的横断面和纵向关联，并在弗雷明汉心脏研究中进行了复制。
在研究队列中观察到炎症蛋白质组发生了广泛变化（60%为女性，35%为非裔美国人），最初体重减轻约 8kg，从研究开始时的中位数 94kg（33/74 种蛋白质；7 种增加；26 种减少），其中许多与接下来 30 个月内体重反弹中位数约 2kg 相关。有 10 种蛋白质与不同的体重反弹率相关，其中一些与趋化和先天免疫反应途径有关。观察到的一些蛋白质关联也与弗雷明汉心脏研究中的普遍肥胖有关。
炎症蛋白质组的广泛变化与体重变化相关，可能确定了改变体重反弹模式的特定途径。
