Department of Chemistry, Analytical Chemistry Division, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia; Central Scientific Methodological Veterinary Laboratory, Orangereynaya st., 23, Moscow 111622, Russia.
Department of Chemistry, Analytical Chemistry Division, Lomonosov Moscow State University, Leninskie Gory, 1/3, Moscow 119991, Russia.
J Chromatogr A. 2022 Dec 6;1685:463620. doi: 10.1016/j.chroma.2022.463620. Epub 2022 Oct 29.
Nitrofurans (NFs) are synthetic broad-spectrum antibacterial and antiparasitic drugs, which recently were extensively used in veterinary practice. In the body of animals, NFs are converted into carcinogenic and mutagenic metabolites that can be accumulated in foods of animal origin having an adverse effect on human health. Therefore, NFs are currently banned in animal husbandry and aquaculture of many countries. However, the data from monitoring the quality of food products indicate that, despite the prohibitions established by the law, they still are used not only in the developing countries but also in the European Union, due to their high antibacterial activity, low cost, and accessibility. Thus, it is of great importance for human health to develop reliable and sensitive analytical methods for monitoring NF metabolites in animal-derived foods. The objective of this review is to summarize the pretreatment strategies and chromatographic methods that have been reported during the last decade for the determination of NF metabolites in food samples, and to outline the future trends with an emphasis on the novel solutions in this area.
硝基呋喃类（NFs）是一种合成的广谱抗菌和抗寄生虫药物，最近在兽医实践中广泛应用。在动物体内，NFs 会转化为致癌和致突变的代谢物，这些代谢物可以在动物源性食品中积累，对人类健康产生不利影响。因此，NFs 目前在许多国家的畜牧业和水产养殖中被禁止使用。然而，从食品质量监测数据来看，尽管法律有明确规定，但由于其高抗菌活性、低成本和易得性，它们不仅在发展中国家，而且在欧盟仍被使用。因此，开发可靠和敏感的分析方法来监测动物源性食品中的 NF 代谢物对人类健康至关重要。本综述的目的是总结过去十年中报道的用于检测食品样品中 NF 代谢物的预处理策略和色谱方法，并概述未来的趋势，重点介绍该领域的新解决方案。
