Department of Hematology, The Second Affiliated Hospital of Nanchang University, No.1 Minde Road, Donghu District, Nanchang, 330006, Jiangxi, People's Republic of China.
Institute of Hematology, Nanchang University, Nanchang, China.
Sci Rep. 2022 Nov 5;12(1):18807. doi: 10.1038/s41598-022-23598-8.
More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors.
越来越多的证据表明 HK2 与肿瘤密切相关。但尚无泛癌症分析。本文旨在基于癌症基因组图谱 (TCGA) 和基因表达综合数据库 (GEO) 的数据集，探讨 HK2 在 33 种肿瘤中的潜在作用。HK2 在大多数肿瘤中高表达，并与一些肿瘤的进展有关。HK2 表达与 T 滤泡辅助细胞浸润有关，在 TCGA 的葡萄膜黑色素瘤、乳腺浸润性癌 (BRCA)、乳腺浸润性癌管腔 A 型 (BRCA-LumA)、头颈部鳞状细胞癌 (HNSC)、人乳头瘤病毒阳性的头颈部鳞状细胞癌 (HNSC-HPV) 和癌症相关成纤维细胞的肿瘤中，以及脑低级别神经胶质瘤和胃腺癌的肿瘤中。我们的首次泛癌症研究提供了对 HK2 在不同肿瘤中作用的相对全面的理解。
