School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Fitoterapia. 2022 Nov;163:105344. doi: 10.1016/j.fitote.2022.105344. Epub 2022 Nov 4.
Four new sesquiterpenes including two guaianes (1 and 2), one germacrene (3), and one nor-sesquiterpene (4), which were named as wenyujinols M-P, along with nine known sesquiterpenes (5-13) and three monoterpenes (14-16), were isolated from the rhizomes of Curcuma wenyujin. The chemical structures of 1-4 were elucidated by NMR spectroscopic, mass spectrometric data, and electronic circular dichroism (ECD) spectra analysis. The isolated compounds were evaluated for antioxidant activity via activating the transcription of Nrf2 in 293 T cells. As a result, compounds 6, 13 and 14 exhibited the Nrf2 agonist activity dose-dependently.
从温郁金根茎中分离得到了 10 个倍半萜类化合物，包括 2 个愈创木烷型倍半萜（1 和 2）、1 个大根香叶型倍半萜（3）和 1 个诺型倍半萜（4），被命名为温郁金醇 M-P。同时，还分离得到了 9 个已知的倍半萜（5-13）和 3 个单萜（14-16）。通过 NMR 光谱、质谱数据和电子圆二色谱（ECD）光谱分析，确定了化合物 1-4 的化学结构。通过在 293T 细胞中激活 Nrf2 的转录，评估了分离得到的化合物的抗氧化活性。结果表明，化合物 6、13 和 14 具有剂量依赖性的 Nrf2 激动剂活性。
