莪术根茎中的 9 种新倍半萜。
Nine new sesquiterpenes from Curcuma wenyujin rhizomes.
机构信息
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
出版信息
Fitoterapia. 2022 Apr;158:105167. doi: 10.1016/j.fitote.2022.105167. Epub 2022 Feb 25.
Nine new sesquiterpenes wenyujinones A-I (1-9), along with ten known ones (10-19), were isolated from the rhizomes of Curcuma wenyujin Y. H. Chen et C. Ling (C. wenyujin). The chemical structures of compounds 1-9 were elucidated by NMR spectroscopic and mass spectrometric data, electronic circular dichroism (ECD) spectra analysis. Furthermore, all compounds were evaluated for the protective effects against hydrogen peroxide (HO)-induced injury in human hepatic L02 cells, for the inhibitory effects on nitric oxide (NO) production in RAW 264.7 cells, and for their cytotoxicity against three human cancer cell lines A549, HL60, and MCF7 in vitro. As a result, compounds 2, 4, 14 markedly weakened the oxidative damage induced by HO in L02 cells via strengthening the cell viability.
从温郁金（Curcuma wenyujin Y. H. Chen et C. Ling）的根茎中分离得到了 9 个新的倍半萜温郁金酮 A-I（1-9）和 10 个已知化合物（10-19）。通过 NMR 光谱和质谱数据、电子圆二色性（ECD）光谱分析确定了化合物 1-9 的化学结构。此外，还评估了所有化合物对人肝 L02 细胞中过氧化氢（HO）诱导损伤的保护作用、对 RAW 264.7 细胞中一氧化氮（NO）生成的抑制作用以及对三种人癌细胞系 A549、HL60 和 MCF7 的体外细胞毒性。结果表明，化合物 2、4、14 通过增强细胞活力显著减弱了 HO 诱导的 L02 细胞氧化损伤。
Zotero 插件