Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, United States.
SRI International, Biosciences Division, Menlo Park, CA, United States.
Life Sci Space Res (Amst). 2022 Nov;35:1-3. doi: 10.1016/j.lssr.2022.10.003. Epub 2022 Oct 12.
Concerns over the health effects of space radiation exposure currently limit the duration of deep-space travel. Effective biological countermeasures could allow humanity to break this limit, facilitating human exploration and sustained presence on the Moon, Mars, or elsewhere in the Solar System. In this issue, we present a collection of 20 articles, each providing perspectives or data relevant to the implementation of a countermeasure discovery and development program. Topics include agency and drug developer perspectives, the prospects for repurposing of existing drugs or other agents, and the potential for adoption of new technologies, high-throughput screening, novel animal or microphysiological models, and alternative ground-based radiation sources. Long-term goals of a countermeasures program include reduction in the risk of radiation-exposure induced cancer death to an acceptable level and reduction in risks to the brain, cardiovascular system, and other organs.
人们对空间辐射暴露的健康影响感到担忧，这限制了深空旅行的时间。有效的生物防护措施可以使人类突破这一限制，从而促进人类在月球、火星或太阳系其他地方的探索和持续存在。在本期特刊中，我们呈现了 20 篇文章，每篇文章都提供了与实施防护措施发现和开发计划相关的观点或数据。这些主题包括机构和药物开发商的观点、重新利用现有药物或其他药物的前景，以及采用新技术、高通量筛选、新型动物或微生理模型和替代地面辐射源的可能性。防护措施计划的长期目标包括将辐射暴露引起的癌症死亡风险降低到可接受的水平，并降低对大脑、心血管系统和其他器官的风险。
