Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Qixia District, China.
Nat Prod Res. 2024 Apr;38(8):1311-1319. doi: 10.1080/14786419.2022.2140150. Epub 2022 Nov 6.
A pair of new quinolone alkaloid enantiomers, ()-(-)-viridicatol () and ()-(+)-viridicatol (), and seven known compounds, namely, , and -, were isolated from SD.84. The structures of and were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed and as a pair of enantiomers. The MIC values of against and methicillin-resistant were 12.4 and 24.7 μM, respectively, compound had no inhibitory activity. Antimicrobial assays of , , and - showed a moderate activity against and methicillin-resistant . This study demonstrated the remarkable potential of sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents.
从 SD.84 中分离得到一对新的喹诺酮生物碱对映异构体（）-（-）-绿堇醇（）和（）-（+）-绿堇醇（），以及 7 种已知化合物，即 、 、 、 、 、 和 -。通过 NMR 和 HRESIMS 数据确定了 和 的结构。通过 CD 和 ECD 的理论计算证实 与 为一对对映异构体。化合物 对 和耐甲氧西林 的 MIC 值分别为 12.4 和 24.7 μM，化合物 没有抑制活性。对 、 和 -的抗菌活性测定表明，它们对 和耐甲氧西林 具有中等活性。本研究表明 sp. 具有产生新的耐药先导化合物的巨大潜力，从而推进了对抗菌药物新来源的挖掘。
