从 SD.84 中分离得到的次生代谢产物及其抗微生物耐药性作用。
Secondary metabolites isolated from SD.84 and their antimicrobial resistance effects.
机构信息
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Qixia District, China.
出版信息
Nat Prod Res. 2024 Apr;38(8):1311-1319. doi: 10.1080/14786419.2022.2140150. Epub 2022 Nov 6.
A pair of new quinolone alkaloid enantiomers, ()-(-)-viridicatol () and ()-(+)-viridicatol (), and seven known compounds, namely, , and -, were isolated from SD.84. The structures of and were determined using NMR and HRESIMS data. Theoretical calculations through CD and ECD confirmed and as a pair of enantiomers. The MIC values of against and methicillin-resistant were 12.4 and 24.7 μM, respectively, compound had no inhibitory activity. Antimicrobial assays of , , and - showed a moderate activity against and methicillin-resistant . This study demonstrated the remarkable potential of sp. to produce new drug-resistant leading compounds, thereby advancing the mining for new sources of antimicrobial agents.
从 SD.84 中分离得到一对新的喹诺酮生物碱对映异构体（）-（-）-绿堇醇（）和（）-（+）-绿堇醇（），以及 7 种已知化合物，即 、 、 、 、 、 和 -。通过 NMR 和 HRESIMS 数据确定了 和 的结构。通过 CD 和 ECD 的理论计算证实 与 为一对对映异构体。化合物 对 和耐甲氧西林 的 MIC 值分别为 12.4 和 24.7 μM，化合物 没有抑制活性。对 、 和 -的抗菌活性测定表明，它们对 和耐甲氧西林 具有中等活性。本研究表明 sp. 具有产生新的耐药先导化合物的巨大潜力，从而推进了对抗菌药物新来源的挖掘。
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