School of Pharmacy, Ningxia Medical University, Yinchuan, China.
Department of Pharmacy, People's Hospital of Ningxia /First Affiliated Hospital of Northwest University for Nationalities, Yinchuan, China.
J Alzheimers Dis. 2023;94(s1):S227-S239. doi: 10.3233/JAD-220651.
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases worldwide. The accumulation of amyloid-β (Aβ) protein and plaque formation in the brain are two major causes of AD. Interestingly, growing evidence demonstrates that the gut flora can alleviate AD by affecting amyloid production and metabolism. However, the underlying mechanism remains largely unknown. This review will discuss the possible association between the gut flora and Aβ in an attempt to provide novel therapeutic directions for AD treatment based on the regulatory effect of Aβ on the gut flora.
阿尔茨海默病（AD）是全球最常见的神经退行性疾病之一。脑内β淀粉样蛋白（Aβ）的堆积和斑块形成是 AD 的两个主要原因。有趣的是，越来越多的证据表明，肠道菌群可以通过影响淀粉样蛋白的产生和代谢来缓解 AD。然而，其潜在机制在很大程度上仍不清楚。本综述将讨论肠道菌群与 Aβ之间可能存在的联系，试图基于 Aβ对肠道菌群的调节作用，为 AD 的治疗提供新的治疗方向。
