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Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis.

作者信息

Zhang Shengzhe, Lee Sung Ho, Nie Litong, Huang Yuanjian, Zou Gengyi, Jung Youn-Sang, Jun Sohee, Zhang Jie, Lien Esther M, Chen Junjie, Park Jae-Il

机构信息

Department of Experimental Radiation Oncology, Division of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Graduate School of Biomedical Sciences, the University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

出版信息

Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6.

DOI:10.1002/cac2.12382
PMID:36336962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9859727/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad9e/9859727/495a47aca474/CAC2-43-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad9e/9859727/495a47aca474/CAC2-43-159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad9e/9859727/495a47aca474/CAC2-43-159-g001.jpg

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TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.TMEM9-v-ATPase 通过 APC 溶酶体降解激活 Wnt/β-连环蛋白信号通路促进肝脏再生和肿瘤发生。
Hepatology. 2021 Feb;73(2):776-794. doi: 10.1002/hep.31305. Epub 2020 Nov 17.
3
Potential new therapy of Rapalink-1, a new generation mammalian target of rapamycin inhibitor, against sunitinib-resistant renal cell carcinoma.
Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study.
血液代谢物作为勃起功能障碍的介质：来自多中心蛋白质组学和遗传学研究的见解
Front Pharmacol. 2025 Jun 2;16:1568780. doi: 10.3389/fphar.2025.1568780. eCollection 2025.
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Comprehensive analysis of TMEM9 in human tumors.人类肿瘤中TMEM9的综合分析。
Discov Oncol. 2025 Mar 7;16(1):276. doi: 10.1007/s12672-025-02040-1.
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Elevated LAMTOR4 Expression Is Associated with Lethal Prostate Cancer and Its Knockdown Decreases Cell Proliferation, Invasion, and Migration In Vitro.LAMTOR4 表达升高与致命性前列腺癌相关，其敲低可减少体外细胞增殖、侵袭和迁移。
Int J Mol Sci. 2024 Jul 25;25(15):8100. doi: 10.3390/ijms25158100.
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Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy.雄激素受体介导的药物基因组学表达数量性状基因座：对 AR 靶向治疗的乳腺癌反应的影响。
Breast Cancer Res. 2024 Jul 4;26(1):111. doi: 10.1186/s13058-024-01861-2.
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