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靶向溶酶体治疗癌症。

Targeting the Lysosome for Cancer Therapy.

机构信息

Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado.

出版信息

Cancer Discov. 2017 Nov;7(11):1218-1220. doi: 10.1158/2159-8290.CD-17-0996.

DOI:10.1158/2159-8290.CD-17-0996
PMID:29097619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5966281/
Abstract

Lysosomes are the recycling centers of the cell where organelles and proteins are degraded during autophagy and macropinocytosis; they also serve as signaling hubs that control the activity of mTORC1. In this issue, Rebecca and colleagues report the development of a new type of lysosomal inhibitor for cancer therapy that can inhibit multiple lysosomal activities that are needed for tumor cell survival and growth. .

摘要

溶酶体是细胞的回收中心，在自噬和巨胞饮过程中细胞器和蛋白质被降解；它们也是控制 mTORC1 活性的信号枢纽。在本期中，Rebecca 及其同事报道了一种新型溶酶体抑制剂的开发，用于癌症治疗，该抑制剂可以抑制肿瘤细胞存活和生长所需的多种溶酶体活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/5966281/9c48ffbe0fd8/nihms966577f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/5966281/9c48ffbe0fd8/nihms966577f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/5966281/9c48ffbe0fd8/nihms966577f1.jpg

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本文引用的文献

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Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.
2
Targeting autophagy in cancer.靶向癌症中的自噬。
Nat Rev Cancer. 2017 Sep;17(9):528-542. doi: 10.1038/nrc.2017.53. Epub 2017 Jul 28.
3
mTOR Signaling in Growth, Metabolism, and Disease.生长、代谢及疾病中的mTOR信号传导
通过纳米药物增强实体瘤中的药物渗透：评估模型、策略与展望。
Bioact Mater. 2023 Oct 26;32:445-472. doi: 10.1016/j.bioactmat.2023.10.017. eCollection 2024 Feb.
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A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer.从新的角度看转录因子 EB 在人类癌症中溶酶体依赖或非依赖的自噬功能。
Acta Pharmacol Sin. 2023 Aug;44(8):1536-1548. doi: 10.1038/s41401-023-01078-7. Epub 2023 Apr 3.
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Biochem Pharmacol. 2023 Feb;208:115387. doi: 10.1016/j.bcp.2022.115387. Epub 2022 Dec 19.
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Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6.
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Targeting Membrane Trafficking as a Strategy for Cancer Treatment.以膜运输为靶点作为癌症治疗策略
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