靶向溶酶体治疗癌症。
Targeting the Lysosome for Cancer Therapy.
机构信息
Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado.
出版信息
Cancer Discov. 2017 Nov;7(11):1218-1220. doi: 10.1158/2159-8290.CD-17-0996.
Abstract
Lysosomes are the recycling centers of the cell where organelles and proteins are degraded during autophagy and macropinocytosis; they also serve as signaling hubs that control the activity of mTORC1. In this issue, Rebecca and colleagues report the development of a new type of lysosomal inhibitor for cancer therapy that can inhibit multiple lysosomal activities that are needed for tumor cell survival and growth. .
摘要
溶酶体是细胞的回收中心，在自噬和巨胞饮过程中细胞器和蛋白质被降解；它们也是控制 mTORC1 活性的信号枢纽。在本期中，Rebecca 及其同事报道了一种新型溶酶体抑制剂的开发，用于癌症治疗，该抑制剂可以抑制肿瘤细胞存活和生长所需的多种溶酶体活性。
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