Khatami Fatemeh, Aghamir Zahra Sadat, Jahanshahi Fatemeh, Feiz-Abadi Seyed Ariana, Birang Fatemeh, Khoshchehreh Mahdi, Namazi Shabestari Alireza, Aghamir Seyed Mohammad Kazem
Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Biotechnol. 2022 Apr 1;20(2):e3094. doi: 10.30498/ijb.2022.294933.3094. eCollection 2022 Apr.
The immune system is directly linked to the tumors, from tumor formation to the tumor's development and metastasis. So, the interest of scientists over the protective immunological mechanisms has increased and shown gifted strategy in cancer treatment.
Genetic engineering and cellular immunotherapy are two different advanced molecular mechanisms to modify the immune responses and genome. Gene manipulation is the bioengineering technology that allows vectors to transfer new genetic information into the target cells. Cellular immunotherapy is an excellent strategy that connects the body's immune system to fight cancer.
RESULTS & CONCLUSIONS: This review described that combination of genetic engineering and cellular immunotherapy has brought the novel antitumor repressive molecules stopping the tumor tissue immune tolerance and significantly expanding cancer therapy's effectiveness. Usually, cell immunotherapy and genetic engineering are considered two independent processes, and, in this review, we believe them in combinations. Here, we review these two novel approaches, and they are both combinations in terms of technological advances and clinical experience.
免疫系统与肿瘤直接相关，从肿瘤形成到肿瘤发展及转移。因此，科学家对保护性免疫机制的兴趣增加，并在癌症治疗中展现出了有前景的策略。
基因工程和细胞免疫疗法是两种不同的先进分子机制，用于调节免疫反应和基因组。基因操作是一种生物工程技术，可使载体将新的遗传信息转移到靶细胞中。细胞免疫疗法是一种将机体免疫系统与抗癌作用联系起来的卓越策略。
本综述表明，基因工程与细胞免疫疗法的联合带来了新型抗肿瘤抑制分子，可阻止肿瘤组织的免疫耐受，并显著提高癌症治疗的效果。通常，细胞免疫疗法和基因工程被视为两个独立的过程，而在本综述中，我们认为它们可以联合使用。在此，我们对这两种新方法进行综述，它们在技术进步和临床经验方面均为联合应用。
