自我选择的限时进食干预对肥胖个体饮食模式、睡眠和夜间进食的影响。
The impact of a self-selected time restricted eating intervention on eating patterns, sleep, and late-night eating in individuals with obesity.
作者信息
Simon Stacey L, Blankenship Jennifer, Manoogian Emily N C, Panda Satchidananda, Mashek Douglas G, Chow Lisa S
机构信息
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
出版信息
Front Nutr. 2022 Oct 21;9:1007824. doi: 10.3389/fnut.2022.1007824. eCollection 2022.
BACKGROUND
Time restricted eating (TRE), limiting eating to a specific daily window, is a novel dietary intervention, but the mechanisms by which TRE results in weight loss remain unclear. The goal of the current study was to examine changes in eating patterns, sleep, and late-night eating, and associations with health outcomes in a secondary analysis of a 12-week self-selected TRE intervention.
METHODS
Twenty participants 18-65 years with BMI ≥25 kg/m2 completed the 12-week trial. Participants randomized to TRE ( = 11) were instructed to eat during a self-selected 8-h window, while the non-TRE group ( = 9) followed their typical eating habits. All participants logged oral intake using the myCircadian Clock mobile application throughout the entire intervention. Anthropometrics, HbA1c, an oral glucose tolerance test, and 2 weeks of actigraphy monitoring were completed at pre-intervention and end-intervention. Independent samples -tests compared differences between groups. Data are presented as mean ± standard deviation.
RESULTS
At preintervention, late night eating was significantly associated with higher fasting glucose (r = 0.59, = 0.006) and higher HbA1c (r = 0.46, = 0.016). The TRE group significantly delayed the timing of the first eating occasion by 2.72 ± 1.48 h relative to wake time ( < 0.001) and advanced the timing of the last eating occasion by 1.25 ± 0.8 h relative to bedtime ( < 0.001). The non-TRE group, on average, maintained their eating pattern. Sleep measures did not change from pre- to end-intervention, however greater restriction of the eating window was associated with longer sleep duration at end-intervention (β = -0.46 [95% CI -9.2, -0.4], = 0.03). The TRE group significantly reduced the prevalence of late night eating (eating within 2 h of bedtime) by 14 ± 6% ( = 0.028) with 63% of participants completely eliminating late night eating at end-intervention.
CONCLUSION
A self-selected TRE intervention significantly shifted meal timing, reduced late-night eating while prolonging sleep duration.
TRIAL REGISTRY
ClinicalTrials.gov, identifier: 03129581.
背景
限时进食（TRE），即将进食限制在特定的每日时间段内，是一种新型的饮食干预方式，但TRE导致体重减轻的机制仍不清楚。本研究的目的是在一项为期12周的自我选择的TRE干预的二次分析中，研究饮食模式、睡眠和夜间进食的变化，以及与健康结果的关联。
方法
20名年龄在18 - 65岁、BMI≥25 kg/m²的参与者完成了为期12周的试验。随机分配到TRE组（n = 11）的参与者被要求在自我选择的8小时时间段内进食,而非TRE组（n = 9）则保持他们的典型饮食习惯。在整个干预过程中，所有参与者使用“我的生物钟”移动应用程序记录口服摄入量。在干预前和干预结束时完成人体测量、糖化血红蛋白（HbA1c）、口服葡萄糖耐量试验以及为期2周的活动记录仪监测。独立样本t检验比较组间差异。数据以平均值±标准差表示。
结果
在干预前，夜间进食与较高的空腹血糖（r = 0.59，P = 0.006）和较高的HbA1c（r = 0.46，P = 0.016）显著相关。TRE组相对于起床时间将首次进食时间显著延迟了2.72±1.48小时（P < 0.001），相对于就寝时间将最后进食时间提前了1.25±0.8小时（P < 0.001）。非TRE组平均保持了他们的饮食模式。从干预前到干预结束，睡眠指标没有变化，然而在干预结束时，进食窗口限制越大与睡眠时间越长相关（β = -0.46[95%CI -9.2，-0.4]，P = 0.03）。TRE组显著降低了夜间进食（就寝时间前2小时内进食）的发生率14±6%（P = 0.028），63%的参与者在干预结束时完全消除了夜间进食。
结论
自我选择的TRE干预显著改变了用餐时间，减少了夜间进食，同时延长了睡眠时间。
试验注册
ClinicalTrials.gov，标识符：03129581。
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