Lalancette Cindy, Leduc Jean-Michel, Malo Jacques, Fournier Éric, Saoud Joseph, Faucher Sébastien P, Pacheco Ana Luisa, Bernard Kathryn, Martineau Christine, Lévesque Simon
Laboratoire de santé publique du Québec, Institut national de santé publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada.
Hôpital du Sacré-Cœur de Montréal, Montréal, Québec, Canada.
J Assoc Med Microbiol Infect Dis Can. 2020 Jun 23;5(2):112-114. doi: 10.3138/jammi-2019-0021. eCollection 2020 Jun.
We describe a strain of isolated from a bronchoalveolar lavage specimen from an 83-year-old patient in the province of Québec. Identification was done using 16S rRNA sequencing. The strain could replicate efficiently in human THP-1 macrophages and maintained a low level of cytotoxicity. Upon analyzing the whole genome sequencing data, the secretion system was present, but the strain lacked some effector genes known to express proteins toxic to cells. The pathogenicity of this species should be investigated further.
我们描述了从魁北克省一名83岁患者的支气管肺泡灌洗标本中分离出的一种菌株。使用16S rRNA测序进行鉴定。该菌株能够在人THP-1巨噬细胞中高效复制，并保持低水平的细胞毒性。在分析全基因组测序数据时，发现存在分泌系统，但该菌株缺乏一些已知可表达对细胞有毒蛋白质的效应基因。该物种的致病性应进一步研究。
