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ADAMTS6：在心血管、肌肉骨骼和癌症生物学中的新作用。

ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology.

作者信息

Mead Timothy J

机构信息

Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, United States.

University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, United States.

出版信息

Front Mol Biosci. 2022 Oct 19;9:1023511. doi: 10.3389/fmolb.2022.1023511. eCollection 2022.

DOI:10.3389/fmolb.2022.1023511
PMID:36339722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9627330/
Abstract

ADAMTS family members control mammalian development and disease, primarily through their function as proteases, by regulation of extracellular matrix composition. Until recently, ADAMTS6 was known as one of the orphan proteinases of the nineteen-member family with a relatively unknown expression pattern and function. Emerging focus on this enzyme has started to uncover these unknowns and revealed a vast importance and requirement of ADAMTS6 in cardiovascular and musculoskeletal development. In addition, ADAMTS6 has been linked to numerous disease settings including several types of cancer. This review summarizes the necessity of ADAMTS6 during development, its role in disease and requirement for essential prospective studies to fully realize its biological implications and potential for therapeutic intervention.

摘要

ADAMTS家族成员主要通过作为蛋白酶发挥作用，调节细胞外基质组成，从而控制哺乳动物的发育和疾病。直到最近，ADAMTS6一直被认为是这个由19个成员组成的家族中的孤儿蛋白酶之一，其表达模式和功能相对未知。对这种酶的新关注开始揭示这些未知因素，并揭示了ADAMTS6在心血管和肌肉骨骼发育中的巨大重要性和需求。此外，ADAMTS6已与多种疾病相关联，包括几种类型的癌症。本综述总结了ADAMTS6在发育过程中的必要性、其在疾病中的作用以及进行必要前瞻性研究以充分认识其生物学意义和治疗干预潜力的需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12b2/9627330/6391509c55bd/fmolb-09-1023511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12b2/9627330/14b2a0ff7886/fmolb-09-1023511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12b2/9627330/6391509c55bd/fmolb-09-1023511-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12b2/9627330/14b2a0ff7886/fmolb-09-1023511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12b2/9627330/6391509c55bd/fmolb-09-1023511-g002.jpg

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