Quach Caroline, Deeks Shelley
Department of Microbiology, Infectious Diseases & Immunology, University of Montreal, Montreal, Quebec, Canada.
Infection Prevention & Control, Department of Clinical Laboratory Medicine, CHU Sainte-Justine, Montreal, Quebec, Canada.
J Assoc Med Microbiol Infect Dis Can. 2021 Mar 25;6(2):73-78. doi: 10.3138/jammi-2021-0323. eCollection 2021 Jun.
On March 3, 2021, faced with ongoing morbidity and mortality from coronavirus disease 2019 (COVID-19) and insufficient supplies of authorized, available vaccines against COVID-19 in Canada, the National Advisory Committee on Immunization (NACI) issued a strong recommendation to allow for an extended interval between vaccine doses to maximize the number of people protected as quickly as possible. NACI's recommendation was released in the form of a rapid response because of the urgency of the situation and was based on a review of the evidence; principles of immunology; historical experience with vaccines; modelling studies; and consideration of ethics, equity, feasibility, and acceptability. Since then, many questions and concerns have been raised. This article aims to provide further explanation of the rationale for the decision and prepare health care providers with information they need as they support their patients in the vaccination rollout.
2021年3月3日,鉴于2019冠状病毒病(COVID-19)持续造成发病和死亡,且加拿大授权可用的COVID-19疫苗供应不足,国家免疫咨询委员会(NACI)发布了一项强烈建议,允许延长疫苗接种剂量之间的间隔时间,以便尽快保护尽可能多的人。由于形势紧迫,NACI的建议以快速反应的形式发布,该建议基于对证据的审查、免疫学原理、疫苗的历史经验、模型研究以及对伦理、公平、可行性和可接受性的考虑。自那时以来,人们提出了许多问题和担忧。本文旨在进一步解释该决定的理由,并为医护人员提供在支持患者进行疫苗接种推广时所需的信息。