García-Muñoz Alejandro, Rodríguez Mario A, Licéaga-Escalera Carlos, Licéaga-Reyes Rodrigo, Carreón-Burciaga Ramón Gil, González-González Rogelio, Bologna-Molina Ronell
School of Dentistry, Universidad Juárez del Estado de Durango, Durango, Mexico; Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F., Mexico.
Department of Infectomics and Molecular Pathogenesis, CINVESTAV-IPN, México, D.F., Mexico.
Arch Oral Biol. 2015 Jun;60(6):799-803. doi: 10.1016/j.archoralbio.2015.02.017. Epub 2015 Feb 28.
Ameloblastic carcinoma is a rare odontogenic tumour that combines the histological features of ameloblastoma with cytological atypia. Until 2005, the incidence of ameloblastic carcinoma was unknown, and since then, fewer than 60 cases have been reported. These tumours may originate from pre-existing tumours or cysts, or they arise de novo from the activation or transformation of embryological cells. PITX2 is a transcription factor that is a product and regulator of the WNT cell signalling pathway, which has been involved in development of several tumours. To analyse whether PITX2 could be involved in the biological behaviour of ameloblastic carcinoma, we analysed the expression of this transcription factor in a sample of this tumour and nine benign ameloblastomas to compare. The results of Western blotting and RT-PCR analyses were positive, and considering the hundreds of genes that PITX2 regulates, we believe that its expression could be intimately linked to the behaviour of ameloblastic carcinoma and possibly other odontogenic lesions.
成釉细胞癌是一种罕见的牙源性肿瘤，它结合了成釉细胞瘤的组织学特征和细胞学异型性。直到2005年，成釉细胞癌的发病率尚不清楚，从那时起，报告的病例不到60例。这些肿瘤可能起源于先前存在的肿瘤或囊肿，或者由胚胎细胞的激活或转化而新发产生。PITX2是一种转录因子，是WNT细胞信号通路的产物和调节因子，该信号通路已参与多种肿瘤的发生发展。为了分析PITX2是否可能参与成釉细胞癌的生物学行为，我们分析了该肿瘤样本和九个良性成釉细胞瘤中这种转录因子的表达以作比较。蛋白质免疫印迹和逆转录聚合酶链反应分析结果呈阳性，考虑到PITX2调控的数百个基因，我们认为其表达可能与成釉细胞癌以及可能的其他牙源性病变的行为密切相关。
