Department of Zoology, Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Aligarh Muslim University, Aligarh-202002, UP, India.
Recent Pat Anticancer Drug Discov. 2023;18(4):428-447. doi: 10.2174/1574892818666221107113648.
Cancer is a global health issue and economic burden with a continuous increase in incidence and mortality. Over the years, the underlying molecular mechanism of cancers was thoroughly researched, leading to multiple drugs' development. Unfortunately, most drugs have some serious drawbacks, such as therapy resistance and toxicity. Epidemiological studies have shown that a diet rich in fruits and vegetables has cancer prevention properties, which shifted the attention to the potential role of phytochemicals in anti-carcinogenic activity.
To review the present status of phytochemicals research and patents in cancer prevention and chemosensitization.
We explored the relevant published articles and patents to review the phytochemicals showing cancer preventive role in preclinical settings from 1997 onwards.
We summarise the role of phytochemicals on anti-carcinogenic, anti-inflammatory, antiproliferative, anti-metastatic, and pro-apoptotic activities in both in vitro and in vivo. Thus, phytochemicals might be an excellent chemosensitizing agent against chemoresistant cells and possibly one of the safest and most effective options for cancer therapy. However, one of the limitations of phytochemicals is their poor bioavailability and rapid excretion. Several analogs have been introduced to increase bioavailability, better biological efficacy, absorption, and retention. In fact, various phytochemicals and their analogs have been patented for their anti-cancerous properties.
This mini-review discusses various phytochemicals and their anti-cancerous and chemosensitizing roles. Due to their clinical relevance, recent trends in phytochemical extraction and exploration have shown that more and more phytochemicals are being patented.
癌症是一个全球性的健康问题和经济负担，其发病率和死亡率持续上升。多年来，癌症的潜在分子机制得到了深入研究，导致了多种药物的开发。然而，大多数药物都有一些严重的缺点，如治疗耐药性和毒性。流行病学研究表明，富含水果和蔬菜的饮食具有防癌特性，这使得人们将注意力转向植物化学物质在抗癌活性中的潜在作用。
综述植物化学物质在癌症预防和化疗增敏中的研究现状和专利情况。
我们探索了相关的已发表文章和专利，以综述自 1997 年以来在临床前研究中具有预防癌症作用的植物化学物质。
我们总结了植物化学物质在抗癌、抗炎、抗增殖、抗转移和促凋亡活性方面的作用，包括在体外和体内的作用。因此，植物化学物质可能是一种对抗耐药细胞的极好的化疗增敏剂，并且可能是癌症治疗中最安全和最有效的选择之一。然而，植物化学物质的局限性之一是其生物利用度差和快速排泄。已经引入了几种类似物来提高生物利用度、更好的生物学功效、吸收和保留。事实上，各种植物化学物质及其类似物已因其抗癌特性而获得专利。
本综述讨论了各种植物化学物质及其抗癌和化疗增敏作用。由于其临床相关性，最近植物化学物质的提取和探索趋势表明，越来越多的植物化学物质正在获得专利。
