Horgan Angela M, Palmbach Gundula R, Jordan Julia M, Callahan Holly S, Meeuws Kaatje E, Weigle David S, Kratz Mario, Purnell Jonathan Q
Clinical Translational Research Center of the Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA.
Institute of Translational Health Sciences, Seattle, WA, USA.
Eur J Nutr. 2023 Mar;62(2):1003-1009. doi: 10.1007/s00394-022-03040-5. Epub 2022 Nov 8.
To determine the effect of an off-protocol meal during a long-term ad libitum feeding study on changes in total caloric consumption and ratings of hunger and satiety.
During the ad libitum portion of a 16 weeks research high-protein feeding study, 19 participants were allowed to eat up to one self-selected meal (SSM) a week instead of an intervention diet meal. The SSM was assessed for total caloric and macronutrient composition and compared to the intervention diet for 3 days before and after the SSM day. Visual analog scores rating daily hunger and fullness were collected and compared as well.
On the SSM day, the mean ± SD daily caloric intake increased by 262 ± 332 kcal compared to the previous study days (P < 0.001), with no changes in subjective appetite scores. The following day there was a slight but significant reduction in intake (- 58 ± 85 kcal, P = 0.008) compared to the average pre-SSM day with no change in appetite scores. On the SSM day, percent protein intake was inversely associated mean daily caloric intake (r = 0.22, P = 0.03).
During a long-term, ad-libitum high-protein feeding study, one SSM lower in protein increased daily total caloric consumption with no impact on appetite ratings and incomplete caloric consumption during subsequent days. These data suggest that during ad-libitum feeding, a single meal change in protein content impacts the relationships between daily level of hunger, satiety and calorie intake.
NCT05002491 (retrospectively registered 07/20/2021).
在一项长期自由进食研究中，确定一顿非方案规定餐对总热量消耗变化以及饥饿和饱腹感评分的影响。
在一项为期16周的高蛋白自由进食研究中，19名参与者被允许每周吃一顿自选餐（SSM），而非干预饮食餐。对SSM的总热量和宏量营养素组成进行评估，并与SSM日前后3天的干预饮食进行比较。同时收集并比较每日饥饿和饱腹感的视觉模拟评分。
在SSM日，与之前的研究日相比，平均每日热量摄入量增加了262±332千卡（P<0.001），主观食欲评分无变化。与SSM日前的平均摄入量相比，第二天摄入量略有但显著减少（-58±85千卡，P=0.008），食欲评分无变化。在SSM日，蛋白质摄入量百分比与平均每日热量摄入量呈负相关（r=0.22，P=0.03）。
在一项长期自由进食的高蛋白喂养研究中，一顿蛋白质含量较低的SSM增加了每日总热量消耗，对食欲评分无影响，且在随后几天热量消耗不完全。这些数据表明，在自由进食期间，蛋白质含量的单次餐食变化会影响每日饥饿、饱腹感和热量摄入之间的关系。
NCT05002491（2021年7月20日追溯注册）
