Mental Health Crisis Prevention and Intervention Research Center, Student Affair Office, Southwest University of Political Science and Law, Chongqing, 401120, China.
Chongqing Key Laboratory of Micro-Nano Systems and Smart Transduction, Chongqing Technology and Business University, Nan'an District, Chongqing, 400067, China.
Biosens Bioelectron. 2023 Jan 15;220:114842. doi: 10.1016/j.bios.2022.114842. Epub 2022 Oct 23.
Bipolar disorder is one of the severe mental diseases. Its high misdiagnosis rate and long-time delayed diagnosis are related to the fact that the diagnosis procedure is mainly conducted by doctors' subjective judgment. The diagnosis methods of bipolar disorder mainly include the International Classification of Diseases (ICD) or the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria and clinical guidelines based on clinical performance. To help psychiatrists make a more accurate diagnosis, in vitro diagnostic (IVD) techniques for bipolar disorder have been developed as the biomarkers research on bipolar disorder steadily increases. Here, we systematically review the recent studies in this area, summarizing the development of instant test products, potentially benefiting clinicians and their patients. The controversy over these biomarkers is discussed, pointing out that multilevel testing with more than one biomarker may provide better confidence in diagnoses. In some cases, more attention should be paid to the different reference values of some biomarkers in terms of age, gender, etc. The review on biomarkers for bipolar disorder may open new doors for the development of point-of-care testing (POCT) and instructing the R&D of future products.
双相情感障碍是一种严重的精神疾病。其误诊率高、诊断时间长，主要与诊断程序主要依靠医生的主观判断有关。双相情感障碍的诊断方法主要包括国际疾病分类（ICD）或精神障碍诊断与统计手册（DSM）标准以及基于临床表现的临床指南。为了帮助精神科医生做出更准确的诊断，随着双相情感障碍的生物标志物研究稳步增加，已经开发出用于双相情感障碍的体外诊断（IVD）技术。在这里，我们系统地回顾了这一领域的最新研究，总结了即时检测产品的发展，这可能使临床医生及其患者受益。本文还讨论了这些生物标志物的争议，指出使用多个生物标志物进行多层次检测可能会为诊断提供更好的信心。在某些情况下，应更加注意一些生物标志物在年龄、性别等方面的不同参考值。双相情感障碍生物标志物的综述可能为即时检测（POCT）的发展开辟新的途径，并为未来产品的研发提供指导。
