半乳糖凝集素-3、红细胞分布宽度、铁调素、高敏 C 反应蛋白和血清铁蛋白与慢性心力衰竭急性发作患者预后的相关性。
Correlation between galectin-3, RDW, Hepc, HS and ferritin and prognosis of patients with acute onset of chronic heart failure.
机构信息
Department of Cardiology, Renmin Hospital, Hubei University of Medicine, No. 39 Chao Yang Road, Shiyan, 442000, Hubei, China.
出版信息
BMC Cardiovasc Disord. 2022 Nov 8;22(1):471. doi: 10.1186/s12872-022-02847-8.
BACKGROUND
Chronic heart failure (CHF) is characterized by a high hospitalization rate and a high mortality rate. It is particularly important to identify biomarkers for predicting the prognosis of patients with acute attack of CHF.
PURPOSE
To observe the correlation between galectin-3, RDW, Hepc, HS and ferritin and the prognosis of patients with acute onset of CHF.
METHODS
The study included 92 patients with acute onset of CHF who received treatment at our hospital between August 2020 and December 2021. After treatment, the patients were divided into the effective group and the non-effective group based on the effectiveness of treatment. The levels of galectin-3, RDW, Hepc, HS and ferritin before and after treatment were compared between the two groups and the correlation between prognosis of patients with acute attack of CHF and galectin-3, RDW, Hepc, HS and ferritin was observed.
RESULTS
The effective rate was 71.74% (66/92) and the ineffective rate was 28.26% (26/92) in the 92 patients with acute attack of CHF in the study. Before and after treatment, the levels of galectin-3, RDW, Hepc, and HS were lower in the effective group than those of the non-effective group while the level of ferritin was higher in the effective group than that of the non-effective group (P < 0.05). Spearman correlation analysis showed that the level of prognosis of patients with acute attack of CHF was positively correlated with galectin-3, RDW, Hepc, and HS (r = 0.217, 0.109, 0.376, 0.765, P = 0.026, 0.032, 0.021, 0.006), and negatively correlated with ferritin (r = - 0.127, P = 0.037). The independent variables were galectin-3, RDW, Hepc, HS and ferritin and the dependent variable was prognosis of patients with acute attack of CHF. Univariate logistic regression analysis showed that alectin-3, RDW, Hepc, HS, and ferritin were protective factors for the prognosis of patients with acute attack of CHF. The independent variables were galectin-3, RDW, Hepc, HS and ferritin, dependent variables and the dependent variable was prognosis of patients with acute attack of CHF. Multivariate logistic regression analysis revealed that galectin-3, RDW, and Hepc were risk factors of the prognosis of patients with acute attack of CHF.
CONCLUSION
Galectin-3, RDW, Hepc, HS and ferritin were closely related with the prognosis of patients with acute attack of CHF and galectin-3, RDW, and Hepc were risk factors of the prognosis of patients with acute attack of CHF.
背景
慢性心力衰竭（CHF）的特征是高住院率和高死亡率。识别预测 CHF 急性发作患者预后的生物标志物尤为重要。
目的
观察半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白与急性发作 CHF 患者预后的相关性。
方法
本研究纳入 2020 年 8 月至 2021 年 12 月在我院接受治疗的 92 例急性发作 CHF 患者。治疗后，根据治疗效果将患者分为有效组和无效组。比较两组患者治疗前后半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白水平，并观察急性发作 CHF 患者预后与半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白的相关性。
结果
92 例急性发作 CHF 患者中，有效率为 71.74%（66/92），无效率为 28.26%（26/92）。治疗前后，有效组患者半乳糖凝集素-3、RDW、Hepc 和 HS 水平均低于无效组，铁蛋白水平高于无效组（P＜0.05）。Spearman 相关性分析显示，急性发作 CHF 患者的预后水平与半乳糖凝集素-3、RDW、Hepc 和 HS 呈正相关（r=0.217、0.109、0.376、0.765，P=0.026、0.032、0.021、0.006），与铁蛋白呈负相关（r=-0.127，P=0.037）。将半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白作为自变量，急性发作 CHF 患者的预后作为因变量进行单因素 logistic 回归分析，结果显示半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白是急性发作 CHF 患者预后的保护因素。将半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白作为自变量，急性发作 CHF 患者的预后作为因变量进行多因素 logistic 回归分析，结果显示半乳糖凝集素-3、RDW 和 Hepc 是急性发作 CHF 患者预后的危险因素。
结论
半乳糖凝集素-3、RDW、Hepc、HS 和铁蛋白与急性发作 CHF 患者的预后密切相关，半乳糖凝集素-3、RDW 和 Hepc 是急性发作 CHF 患者预后的危险因素。
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