European Laboratory for Non-linear Spectroscopy, University of Florence, 50019 Sesto Fiorentino, Italy; Department of Physics and Astronomy, University of Florence, 50019 Sesto Fiorentino, Italy.
European Laboratory for Non-linear Spectroscopy, University of Florence, 50019 Sesto Fiorentino, Italy; Department of Physics and Astronomy, University of Florence, 50019 Sesto Fiorentino, Italy.
Cell Rep. 2022 Nov 8;41(6):111627. doi: 10.1016/j.celrep.2022.111627.
In rodent motor cortex, the rostral forelimb area (RFA) and the caudal forelimb area (CFA) are major actors in orchestrating the control of complex forelimb movements. However, their intrinsic connectivity and reciprocal functional organization are still unclear, limiting our understanding of how the brain coordinates and executes voluntary movements. Here, we causally probe cortical connectivity and activation patterns triggered by transcranial optogenetic stimulation of ethologically relevant complex movements exploiting a large-scale all-optical method in awake mice. Results show specific activation features for each movement class, providing evidence for a segregated functional organization of CFA and RFA. Importantly, we identify a second discrete lateral grasping representation area, namely the lateral forelimb area (LFA), with unique connectivity and activation patterns. Therefore, we propose the LFA as a distinct forelimb representation in the mouse somatotopic motor map.
在啮齿动物运动皮层中，额侧前肢区（RFA）和尾侧前肢区（CFA）是协调复杂前肢运动控制的主要区域。然而，它们的内在连接和相互功能组织尚不清楚，这限制了我们对大脑如何协调和执行自主运动的理解。在这里，我们利用一种在清醒小鼠中进行的大规模全光学方法，对与行为相关的复杂运动进行经颅光遗传刺激，从而对皮层连接和激活模式进行因果探测。结果表明，每种运动类别的激活特征都不同，这为 CFA 和 RFA 的分离功能组织提供了证据。重要的是，我们确定了第二个离散的外侧抓握代表区域，即外侧前肢区（LFA），其具有独特的连接和激活模式。因此，我们提出 LFA 作为小鼠躯体运动图谱中独特的前肢代表区域。
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