Tavakolifard Negah, Moeini Mina, Haddadpoor Asefeh, Amini Zahra, Heidari Kamal, Rezaie Mostafa
Department of Community and Family Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Vice Chancellor for Health, Isfahan University Of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2022 Sep 27;27:75. doi: 10.4103/jrms.jrms_1387_20. eCollection 2022.
The first confirmed case of COVID-19 in Iran was reported in February 2019. The current study aimed to investigate the epidemiological aspects of COVID-19 disease in Isfahan province and evaluate the chances of infection and death in the population.
In this cross-sectional study, 21,203 confirmed cases of COVID-19, based on the polymerase chain reaction test, referred to outpatient facilities from February 2019 to July 2020 in Isfahan province are studied. Disease incidence, mortality, and case fatality rate, as well as odds ratio (OR) of infection and death, were calculated and analyzed using SPSS version 20.
The highest incidence of the disease was within the age group of 30-39 years 4911 (23.9%) and males 11,561 (54.5%). Mortality in people over 80 years (207 [32.9%]), men (370 cases [58.7%]), diabetics (182 cases [28.9%]), and people with cardiovascular disease (165 people [26.2%]) was more. In multivariate analysis, patients with a cancer diagnosis had the highest OR of death (OR = 4.03 confidence interval [CI]: 2.56-6.35) ( < 0.001), followed by those with immune deficiency disease (OR = 2.46 CI: 1.07-5.63) ( = 0.03). As the number of comorbidities increased, the risk of death increased in the total population, so that in patients with more than 4 underlying diseases, compared to the group without disease, the chance of death increased 6.33 times.
This study showed that people with cancer and chronic respiratory disease had a higher chance of COVID-19 infection. People over the age of 60, people with cancer, and immunodeficiency also had a higher chance of COVID-19 mortalityW.
伊朗第一例确诊的COVID-19病例于2019年2月报告。本研究旨在调查伊斯法罕省COVID-19疾病的流行病学特征，并评估人群中的感染和死亡几率。
在这项横断面研究中，对2019年2月至2020年7月期间基于聚合酶链反应检测确诊的21203例COVID-19病例进行了研究，这些病例均转诊至伊斯法罕省的门诊机构。使用SPSS 20版计算并分析了疾病发病率、死亡率、病死率以及感染和死亡的比值比（OR）。
疾病发病率最高的年龄组为30 - 39岁，共4911例（23.9%），男性为11561例（54.5%）。80岁以上人群（207例 [32.9%]）、男性（370例 [58.7%]）、糖尿病患者（182例 [28.9%]）和心血管疾病患者（165例 [26.2%]）的死亡率更高。在多变量分析中，被诊断患有癌症的患者死亡OR最高（OR = 4.03，置信区间 [CI]：2.56 - 6.35）（P < 0.001），其次是免疫缺陷疾病患者（OR = 2.46，CI：1.07 - 5.63）（P = 0.03）。随着合并症数量的增加，总人群的死亡风险增加，因此，与无基础疾病组相比，患有4种以上基础疾病的患者死亡几率增加了6.33倍。
本研究表明，患有癌症和慢性呼吸道疾病的人群感染COVID-19的几率更高。60岁以上人群、癌症患者和免疫缺陷人群的COVID-19死亡几率也更高。
