Sumiyoshi Tomiki, Uchida Hiroyuki, Watanabe Koichiro, Oosawa Masato, Ren Hongye, Moriguchi Yoshiya, Fujikawa Keita, Fernandez Jovelle
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Neuropsychiatr Dis Treat. 2022 Nov 2;18:2507-2517. doi: 10.2147/NDT.S381647. eCollection 2022.
To validate the five-item version of the Perceived Deficits Questionnaire for Depression (PDQ-D-5) for assessing subjective cognitive function in Japanese patients with major depressive disorder (MDD) using data from the PERFORM-J study.
A total of 518 Japanese outpatients diagnosed with MDD were assessed on severity of depressive symptoms, cognitive function, social and work function, and quality of life (QoL) over 6 months following initiation of antidepressant therapy. This post hoc analysis evaluated the internal consistency and convergent validity of the PDQ-D-5 in relation to the original PDQ-D-20. Correlations of scores on these measures were examined at each time point and over time. The same set of analyses was explored between PDQ-D-5 and the Patient Health Questionnaire-nine-item (PHQ-9), Montgomery-Asberg Depression Rating Scale (MADRS), Digit Symbol Substitution Test (DSST), five-level version of EQ-5D (EQ-5D-5L), Sheehan Disability Scale (SDS), and Work Productivity and Activity Impairment (WPAI) questionnaire.
PDQ-D-5 scores showed good internal consistency. Strong positive correlations were observed between PDQ-D-5 and PDQ-D-20 at each time point (correlation coefficient: baseline, 0.94; month 1, 0.94; month 2, 0.96; month 6, 0.96) and over time (0.92) (all p < 0.0001). Longitudinally, there were positive correlations between PDQ-D-5 scores versus those on the PHQ-9, MADRS, and SDS. Similarly, negative correlations were noted between PDQ-D-5 scores and EQ-5D-5L and DSST scores to a variable degree. There were moderate positive correlations over time between PDQ-D-5 and all WPAI subscale scores except those on absenteeism.
PDQ-D-5 scores rated in Japanese patients with MDD were found to adequately represent scores on the PDQ-D-20. The short version also showed associations with several measures of functional outcome, depression severity and QoL. This validates the PDQ-D-5 as a feasible and clinically reliable tool to assess subjective experience on cognition, which is applicable to time-limited consultations.
UMIN000024320.
利用PERFORM-J研究的数据，验证用于评估日本重度抑郁症（MDD）患者主观认知功能的抑郁感知缺陷问卷五项版（PDQ-D-5）。
共有518名被诊断为MDD的日本门诊患者在开始抗抑郁治疗后的6个月内接受了抑郁症状严重程度、认知功能、社会和工作功能以及生活质量（QoL）的评估。这项事后分析评估了PDQ-D-5相对于原始PDQ-D-20的内部一致性和收敛效度。在每个时间点以及随时间推移，检查了这些测量指标得分之间的相关性。在PDQ-D-5与患者健康问卷九项版（PHQ-9）、蒙哥马利-阿斯伯格抑郁评定量表（MADRS）、数字符号替换测验（DSST）、EQ-5D五级版（EQ-5D-5L）、希恩残疾量表（SDS）以及工作效率和活动障碍（WPAI）问卷之间进行了相同的一组分析。
PDQ-D-5得分显示出良好的内部一致性。在每个时间点（相关系数：基线时为0.94；第1个月时为0.94；第2个月时为0.96；第6个月时为0.96）以及随时间推移（0.92），PDQ-D-5与PDQ-D-20之间均观察到强正相关（所有p<0.0001）。纵向来看，PDQ-D-5得分与PHQ-9、MADRS和SDS得分之间存在正相关。同样地，PDQ-D-5得分与EQ-5D-5L和DSST得分在不同程度上存在负相关。随着时间推移，PDQ-D-5与除旷工外的所有WPAI子量表得分之间存在中度正相关。
发现日本MDD患者的PDQ-D-评分能充分代表PDQ-D-20的得分。这个简短版本还显示出与功能结局、抑郁严重程度和生活质量的多项测量指标相关。这验证了PDQ-D-5作为一种可行且临床可靠的工具，可用于评估认知方面的主观体验，适用于限时咨询。
主要研究的UMIN临床试验注册编号：UMIN000024320。
