Wang Zijian, Liu Jiarui, Xie Jingri, Yuan Xingxing, Wang Bingyu, Shen Wenjuan, Zhang Yang
Graduate College, Heilongjiang University of Chinese Medicine, Harbin, China.
College of Life Science and Technology, Guangxi University, Nanning, China.
Front Oncol. 2022 Oct 24;12:947332. doi: 10.3389/fonc.2022.947332. eCollection 2022.
Autophagy is a conserved cellular self-digesting process that degrades obsoleting proteins and cellular components and plays a crucial role in the tumorigenesis, metastasis, and drug resistance of various tumors such as gastric cancer (GC). As a hotspot in molecular biology, non-coding RNAs (ncRNAs) are involved in the regulation of multiple biological processes, such as autophagy. Increasing evidence indicate that various ncRNAs exert double roles in the initiation and progression of GC, either serve as oncogenes or tumor suppressors. Recent studies have shown that some ncRNAs could modulate autophagy activity in GC cells, which would affect the malignant transformation and drug resistance. Whether the function of ncRNAs in GC is dependent on autophagy is undefined. Therefore, identifying the underlying moleculr targets of ncRNAs in autophagy pathways and the role of ncRNA-regulated autophagy in GC could develop new treatment interventions for this disease. This review summarizes the autophagy process and its role in GC, and the regulatory mechanisms of ncRNAs, as well as focuses on the dual role of ncRNAs-mediated autophagy in GC, for the development of potential therapeutic strategies in GC patients.
自噬是一种保守的细胞自我消化过程，可降解过时的蛋白质和细胞成分，在胃癌（GC）等各种肿瘤的发生、转移和耐药性中起关键作用。作为分子生物学的一个热点，非编码RNA（ncRNAs）参与多种生物学过程的调控，如自噬。越来越多的证据表明，各种ncRNAs在GC的发生和发展中发挥双重作用，既可以作为癌基因，也可以作为肿瘤抑制因子。最近的研究表明，一些ncRNAs可以调节GC细胞中的自噬活性，这将影响恶性转化和耐药性。ncRNAs在GC中的功能是否依赖于自噬尚不清楚。因此，确定ncRNAs在自噬途径中的潜在分子靶点以及ncRNA调节的自噬在GC中的作用，可能会为这种疾病开发新的治疗干预措施。本综述总结了自噬过程及其在GC中的作用、ncRNAs的调控机制，并重点探讨了ncRNAs介导的自噬在GC中的双重作用，以期为GC患者开发潜在的治疗策略。
