CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing 100190, China.
School of Nanoscience and Technology, University of the Chinese Academy of Sciences, Beijing 100049, China.
Biosensors (Basel). 2022 Nov 1;12(11):957. doi: 10.3390/bios12110957.
As chiral antennas, plasmonic nanoparticles (NPs) can enhance chiral responses of chiral materials by forming hybrid structures and improving their own chirality preference as well. Chirality-dependent properties of plasmonic NPs broaden application potentials of chiral nanostructures in the biomedical field. Herein, we review the wet-chemical synthesis and self-assembly fabrication of gold-NP-based chiral nanostructures. Discrete chiral NPs are mainly obtained via the seed-mediated growth of achiral gold NPs under the guide of chiral molecules during growth. Irradiation with chiral light during growth is demonstrated to be a promising method for chirality control. Chiral assemblies are fabricated via the bottom-up assembly of achiral gold NPs using chiral linkers or guided by chiral templates, which exhibit large chiroplasmonic activities. In describing recent advances, emphasis is placed on the design and synthesis of chiral nanostructures with the tuning and amplification of plasmonic circular dichroism responses. In addition, the review discusses the most recent or even emerging trends in biomedical fields from biosensing and imaging to disease diagnosis and therapy.
作为手性天线，等离子体纳米粒子（NPs）可以通过形成杂化结构和提高自身的手性偏好来增强手性材料的手性响应。等离子体 NPs 的手性依赖性特性拓宽了手性纳米结构在生物医学领域的应用潜力。本文综述了基于金-NP 的手性纳米结构的湿化学合成和自组装制备。离散的手性 NPs 主要通过在手性分子的引导下，在非手性金 NPs 的种子介导生长过程中获得。在生长过程中用手性光照射被证明是一种控制手性的有前途的方法。通过使用手性连接子或在手性模板的引导下，自下而上地组装非手性金 NPs 来制备手性组装体，它们表现出较大的手性等离子体活性。在描述最新进展时，重点介绍了手性纳米结构的设计和合成，以及等离子体圆二色性响应的调节和放大。此外，本文还讨论了生物医学领域中从生物传感和成像到疾病诊断和治疗的最新甚至新兴趋势。
