Department of Biological Systems Engineering, University of Wisconsin-Madison, 460 Henry Mall, Madison, WI 53706, USA.
Biosensors (Basel). 2022 Nov 7;12(11):982. doi: 10.3390/bios12110982.
MXene is a two-dimensional (2D) nanomaterial that exhibits several superior properties suitable for fabricating biosensors. Likewise, the nucleic acid (NA) in oligomerization forms possesses highly specific biorecognition ability and other features amenable to biosensing. Hence the combined use of MXene and NA is becoming increasingly common in biosensor design and development. In this review, MXene- and NA-based biosensors are discussed in terms of their sensing mechanisms and fabrication details. MXenes are introduced from their definition and synthesis process to their characterization followed by their use in NA-mediated biosensor fabrication. The emphasis is placed on the detection of various targets relevant to agricultural and food systems, including microbial pathogens, chemical toxicants, heavy metals, organic pollutants, etc. Finally, current challenges and future perspectives are presented with an eye toward the development of advanced biosensors with improved detection performance.
MXene 是一种二维（2D）纳米材料，具有多种适合于制造生物传感器的优异性能。同样，聚合形式的核酸（NA）具有高度特异性的生物识别能力和其他适合生物传感的特性。因此，MXene 和 NA 的联合使用在生物传感器的设计和开发中变得越来越普遍。在本综述中，讨论了基于 MXene 和 NA 的生物传感器在传感机制和制造细节方面的应用。从 MXene 的定义和合成过程到其表征，再到其在 NA 介导的生物传感器制造中的应用，对 MXene 进行了介绍。重点介绍了检测与农业和食品系统相关的各种目标物，包括微生物病原体、化学毒物、重金属、有机污染物等。最后，提出了当前的挑战和未来的展望，以期开发具有改进检测性能的先进生物传感器。
