Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha 410013, China.
Chengdu Pep Biomedical Co., Ltd., Chengdu 610041, China.
Toxins (Basel). 2022 Nov 2;14(11):753. doi: 10.3390/toxins14110753.
Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a novel wound-healing promoting peptide, PM-7, was identified from the skin secretions of , which has an amino acid sequence of FLNWRRILFLKVVR and shares no structural similarity with any peptides described before. It displays the activity of promoting wound healing in mice. Moreover, PM-7 exhibits the function of enhancing proliferation and migration in HUVEC and HSF cells by affecting the MAPK signaling pathway. Considering its favorable traits as a novel peptide that significantly promotes wound healing, PM-7 can be a potential candidate in the development of novel wound-repairing drugs.
蛙类皮肤含有多种具有促进伤口愈合、抗菌和释放胰岛素功能的肽类物质，这使它们的皮肤具有很强的再生能力，以适应复杂而恶劣的生活环境。在目前的研究中，从 皮肤分泌物中鉴定出一种新型的促进伤口愈合的肽 PM-7，其氨基酸序列为 FLNWRRILFLKVVR，与以前描述的任何肽都没有结构相似性。它在小鼠中显示出促进伤口愈合的活性。此外，PM-7 通过影响 MAPK 信号通路，表现出增强 HUVEC 和 HSF 细胞增殖和迁移的功能。鉴于其作为一种新型显著促进伤口愈合的肽的优良特性，PM-7 可能成为新型伤口修复药物开发的潜在候选药物。
