Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an 710048, China.
Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an 710048, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Feb 15;287(Pt 2):122075. doi: 10.1016/j.saa.2022.122075. Epub 2022 Nov 5.
The rapid and accurate identification of the types and contents of early pathological markers by THz technology are of particular importance for the prevention and treatment of major diseases. Nevertheless, these markers usually contain interference from water and other non-target molecules, resulting in low signal-to-noise ratio (SNR) and making identification and quantitative analysis difficult. Here, based on THz spectroscopy from a high-power THz source radiated by LiNbO, we perform quantitative and real-time THz detection of mixtures (α-lactose monohydrate and 4-aminobenzoic acid) in liquids. The results demonstrate that the absorption spectra of the aqueous biomolecular mixtures exhibit an accumulation of THz features of each pure product, i.e., the amplitude of the absorption peaks is proportional to the mixing ratio, while the corresponding absorption baseline increases with decreasing concentration. Furthermore, the content of the target substance can be calculated from the linear relationship between the absorption spectra of pure and mixed samples. This technology will support the future application of THz-TDS in early disease diagnosis under complex states and environments.
太赫兹技术对快速准确地识别早期病理标志物的类型和含量具有重要意义，这对于重大疾病的预防和治疗至关重要。然而，这些标志物通常包含来自水和其他非目标分子的干扰，导致信噪比（SNR）低，难以进行识别和定量分析。在这里，我们基于 LiNbO 辐射的高功率太赫兹源的太赫兹光谱，对液体混合物（α-乳糖一水合物和 4-氨基苯甲酸）进行了定量和实时太赫兹检测。结果表明，水生物分子混合物的吸收光谱表现出各纯产物的太赫兹特征的积累，即吸收峰的幅度与混合比成正比，而相应的吸收基线随浓度的降低而增加。此外，可以根据纯样品和混合样品的吸收光谱之间的线性关系计算目标物质的含量。这项技术将支持太赫兹时域光谱技术在复杂状态和环境下进行早期疾病诊断的未来应用。
