Wang Haiqing, Shi Wei, Hou Lei, Li Chunhui, Zhang Yusong, Yang Lei, Cao Juncheng
Key Laboratory of Ultrafast Photoelectric Technology and Terahertz Science in Shaanxi, Xi'an University of Technology, Xi'an, China.
School of Physics and Opto-Electronic Technology, Baoji Key Laboratory of Micro-Nano Optoelectronics and Terahertz Technology, Baoji University of Arts and Sciences, Baoji, Shaanxi, China.
Front Bioeng Biotechnol. 2023 Mar 23;11:1170218. doi: 10.3389/fbioe.2023.1170218. eCollection 2023.
Terahertz (THz) technology has emerged as a promising tool for the qualitative and quantitative identification of markers containing major diseases, enabling early diagnosis and staged treatment of diseases. Nevertheless, the detection of water-containing biological samples is facing significant challenges due to limitations in high-power THz radiation sources and high-sensitivity detection devices. In this paper, we present a designed and constructed set of Terahertz-Attenuated Total Reflection (THz-ATR) spectrometer for high-sensitivity detection of liquid biological samples, which can dynamically maintain the signal-to-noise ratio (SNR) of THz detection signal of liquid biological samples at 40-60 dB. Our high-power THz-ATR spectroscopy can identify and quantitatively detect α-lactose aqueous solution with a minimum concentration of 0.292 mol/L. Moreover, we observed that the rate of change in the absorption peak position varied greatly between high and low concentration samples. Our high-power, high-sensitivity THz-ATR spectroscopy detection provides a rapid, accurate, and low-cost method for detecting disease markers such as blood and urine indicators. Additionally, this approach offers new perspectives for the refinement and in-depth detection of biomedical samples.
太赫兹（THz）技术已成为一种有前景的工具，可用于定性和定量识别包含重大疾病的标志物，实现疾病的早期诊断和分期治疗。然而，由于高功率太赫兹辐射源和高灵敏度检测设备的限制，含水生物样品的检测面临重大挑战。在本文中，我们设计并构建了一套太赫兹衰减全反射（THz-ATR）光谱仪，用于高灵敏度检测液体生物样品，该光谱仪可将液体生物样品的太赫兹检测信号的信噪比（SNR）动态保持在40 - 60 dB。我们的高功率THz-ATR光谱能够识别并定量检测最低浓度为0.292 mol/L的α-乳糖水溶液。此外，我们观察到高浓度和低浓度样品之间吸收峰位置的变化速率差异很大。我们的高功率、高灵敏度THz-ATR光谱检测为检测血液和尿液指标等疾病标志物提供了一种快速、准确且低成本的方法。此外，这种方法为生物医学样品的细化和深度检测提供了新的视角。
