非靶向代谢组学用于描述在不同培养基中生长的 属菌丝体提取物的化学成分、抗氧化和抗菌作用。 （注：原文中“ spp.”部分信息缺失，无法准确完整翻译这部分内容）
Untargeted Metabolomics Used to Describe the Chemical Composition, Antioxidant and Antimicrobial Effects of Extracts from spp. Mycelium Grown in Different Culture Media.
作者信息
Flores Giancarlo Angeles, Girometta Carolina Elena, Cusumano Gaia, Angelini Paola, Tirillini Bruno, Ianni Federica, Blasi Francesca, Cossignani Lina, Pellegrino Roberto Maria, Emiliani Carla, Venanzoni Roberto, Venturella Giuseppe, Colasuonno Pasqualina, Cirlincione Fortunato, Gargano Maria Letizia, Zengin Gokhan, Acquaviva Alessandra, Di Simone Simonetta Cristina, Orlando Giustino, Menghini Luigi, Ferrante Claudio
机构信息
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06122 Perugia, Italy.
Department of Earth and Environmental Sciences (DSTA), University of Pavia, 27100 Pavia, Italy.
出版信息
Antibiotics (Basel). 2022 Oct 25;11(11):1468. doi: 10.3390/antibiotics11111468.
species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among samples covered a total of 58 pathways. Comparisons were made between the metabolic profiles of spp. mycelia grown in two substrates: Potato-dextrose-agar-PDA, used as control (S1), and PDA enriched with 0.5 % of wheat straw (S2). The main finding was that the metabolic pathways are strongly influenced by the chemical composition of the growth substrate. The antibacterial effects were particularly evident against , whereas (CCF 5207) and (CCF 4933) were the dermatophytes more sensitive to the mushroom extracts. The present study supports more in-depth investigations, aimed at evaluating the influence of growth substrate on spp. antimicrobial and antioxidant properties.
对体外分离出的物种进行了研究，以确定不同培养基对其次生代谢产物产生、抗菌和抗氧化活性的影响。样品中的不同代谢产物总共涉及58条途径。对在两种基质中生长的 spp. 菌丝体的代谢谱进行了比较：用作对照的马铃薯葡萄糖琼脂（PDA）（S1）和添加了0.5%麦秸的PDA（S2）。主要发现是代谢途径受到生长基质化学成分的强烈影响。抗菌作用对 尤为明显，而 （CCF 5207）和 （CCF 4933）是对蘑菇提取物更敏感的皮肤癣菌。本研究支持更深入的调查，旨在评估生长基质对 spp. 抗菌和抗氧化特性的影响。
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