Luo Yusong, Tian Guopeng, Fang Xiang, Bai Shengwei, Yuan Guoqiang, Pan Yawen
Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou 730030, China.
Key Laboratory of Neurology of Gansu Province, Lanzhou 730030, China.
Antioxidants (Basel). 2022 Oct 28;11(11):2123. doi: 10.3390/antiox11112123.
Glioma is the most common intracranial malignant tumor, and the current main standard treatment option is a combination of tumor surgical resection, chemotherapy and radiotherapy. Due to the terribly poor five-year survival rate of patients with gliomas and the high recurrence rate of gliomas, some new and efficient therapeutic strategies are expected. Recently, ferroptosis, as a new form of cell death, has played a significant role in the treatment of gliomas. Specifically, studies have revealed key processes of ferroptosis, including iron overload in cells, occurrence of lipid peroxidation, inactivation of cysteine/glutathione antiporter system Xc (xCT) and glutathione peroxidase 4 (GPX4). In the present review, we summarized the molecular mechanisms of ferroptosis and introduced the application and challenges of ferroptosis in the development and treatment of gliomas. Moreover, we highlighted the therapeutic opportunities of manipulating ferroptosis to improve glioma treatments, which may improve the clinical outcome.
胶质瘤是最常见的颅内恶性肿瘤，目前主要的标准治疗方案是肿瘤手术切除、化疗和放疗相结合。由于胶质瘤患者的五年生存率极低且胶质瘤复发率高，因此人们期待一些新的有效治疗策略。最近，铁死亡作为一种新的细胞死亡形式，在胶质瘤治疗中发挥了重要作用。具体而言，研究揭示了铁死亡的关键过程，包括细胞内铁过载、脂质过氧化的发生、半胱氨酸/谷胱甘肽反向转运体系统Xc（xCT）和谷胱甘肽过氧化物酶4（GPX4）的失活。在本综述中，我们总结了铁死亡的分子机制，并介绍了铁死亡在胶质瘤发生发展和治疗中的应用及挑战。此外，我们强调了通过调控铁死亡改善胶质瘤治疗的潜在机会，这可能改善临床疗效。
