Department of Physical and Colloid Chemistry, Kazan National Research Technological University, Kazan 420015, Russia.
Zavoisky Physical-Technical Institute, FRC Kazan Scientific Center of RAS, Kazan 420029, Russia.
Int J Mol Sci. 2022 Oct 30;23(21):13207. doi: 10.3390/ijms232113207.
Chitosan or its derivatives exhibit lyotropic liquid crystalline mesophases under certain conditions due to its semi-rigid structures. This work describes the development of chitosan-based biocompatible systems that include new components: lactic acid and non-ionic surfactants. Polarized optical microscopy studies revealed that these systems are capable of forming gels or lyotropic liquid crystals (LLCs) in a certain range of chitosan and lactic acid concentrations. According to the viscosity studies, the rheological flow of the LLCs can be accurately described by the Casson flow model. The intermolecular interactions of the LLC components were studied by FTIR spectroscopy. According to the FTIR data, hydrogen bonding is supposed to be responsible for the formation of the LLCs. In the studied systems, this LLC complex exists as the [ChitH·CH-CH(OH)-COO] ion pair. The studied gel and LLCs were shown to possess the most prolonged release capabilities for riboflavin among similar binary LLC systems. The supramolecular organization and rheological characteristics of the studied chitosan-based systems were found to affect the release of riboflavin.
壳聚糖或其衍生物由于其半刚性结构，在某些条件下表现出溶致液晶中间相。本工作描述了壳聚糖基生物相容性体系的发展，该体系包括新的成分：乳酸和非离子表面活性剂。偏光显微镜研究表明，这些体系在壳聚糖和乳酸浓度的一定范围内能够形成凝胶或溶致液晶（LLC）。根据粘度研究，Casson 流模型可以准确地描述 LLC 的流变流动。通过傅里叶变换红外光谱研究 LLC 组分的分子间相互作用。根据傅里叶变换红外光谱数据，氢键被认为是形成 LLC 的原因。在研究的体系中，这种 LLC 复合物以[ChitH·CH-CH（OH）-COO]离子对的形式存在。研究表明，在类似的二元 LLC 体系中，所研究的凝胶和 LLC 对核黄素具有最长的释放能力。发现研究的基于壳聚糖的体系的超分子组织和流变特性影响核黄素的释放。
