用于治疗疱疹病毒感染的功能化贵金属纳米颗粒
Functionalized Noble Metal Nanoparticles for the Treatment of Herpesvirus Infection.
作者信息
Janicka Martyna, Ranoszek-Soliwoda Katarzyna, Chodaczek Grzegorz, Antos-Bielska Małgorzata, Brytan Marek, Tomaszewska Emilia, Celichowski Grzegorz, Grobelny Jarosław, Cymerys Joanna, Krzyżowska Małgorzata, Chodkowski Marcin
机构信息
Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
Division of Microbiology, Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-786 Warsaw, Poland.
出版信息
Microorganisms. 2022 Oct 31;10(11):2161. doi: 10.3390/microorganisms10112161.
Neuroinfections caused by herpesviruses, mainly by HHV-1, represent a significant problem for modern medicine due to the small number of therapeutic substances available in the pharmaceutical sector. Furthermore, HHV-1 infection has been linked to neurodegenerative processes such as Alzheimer's disease, which justifies the search for new effective therapies. The development of nanotechnology opens up new possibilities for the treatment of neuroinflammation. Gold and silver nanoparticles are gaining popularity, and the number of clinical trials involving metallic nanoparticles is constantly increasing. This paper reviews the research on gold and silver nanoparticles and their potential use in the treatment of herpesvirus neuroinfection.
由疱疹病毒引起的神经感染，主要是由HHV - 1引起的，由于制药领域可用的治疗药物数量较少，对现代医学来说是一个重大问题。此外，HHV - 1感染与神经退行性过程如阿尔茨海默病有关，这使得寻找新的有效疗法成为必要。纳米技术的发展为神经炎症的治疗开辟了新的可能性。金和银纳米颗粒越来越受欢迎，涉及金属纳米颗粒的临床试验数量也在不断增加。本文综述了金和银纳米颗粒的研究及其在治疗疱疹病毒神经感染中的潜在用途。
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