Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, India.
Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599-7575, USA.
Biosensors (Basel). 2021 Apr 15;11(4):122. doi: 10.3390/bios11040122.
Organotrialkoxysilanes like 3-aminopropyltrimethoxysilane (3-APTMS)-treated noble metal cations were rapidly converted into their respective nanoparticles in the presence of 3-glycidoxypropylytrimethoxysilane (3-GPTMS). The micellar activity of 3-APTMS also allowed us to replace 3-GPTMS with other suitable organic reagents (e.g., formaldehyde); this approach has significant advantages for preparing bimetallic and trimetallic analogs of noble metal nanoparticles that display efficient activity in many practical applications. The formation of monometallic gold, silver, and palladium nanoparticles, bimetallic Ag-Pd, and Au-Pd nanoparticles at various ratios of noble metal cations, and trimetallic Ag-Au-Pd nanoparticles were studied; their biocatalytic activity in non-enzymatic sensing of glucose based on monitoring synchronous fluorescence spectroscopy (SFS) was assessed. Of these nanoparticles, Au-Pd made with an 80:20 Au:Pd ratio displayed excellent catalytic activity for glucose sensing. These nanoparticles could also be homogenized with Nafion to enhance the resonance Rayleigh scattering (RRS) signal. In this study, the structural characterization of noble metal nanoparticles as well as bi- and tri-metallic nanoparticles in addition to their use in non-enzymatic sensing of glucose are reported.
有机三烷氧基硅烷，如 3-氨丙基三甲氧基硅烷（3-APTMS）-处理的贵金属阳离子，在 3-缩水甘油丙基三甲氧基硅烷（3-GPTMS）的存在下迅速转化为各自的纳米粒子。3-APTMS 的胶束活性还允许我们用其他合适的有机试剂（如甲醛）代替 3-GPTMS；这种方法在制备显示许多实际应用中高效活性的贵金属纳米粒子的双金属和三金属类似物方面具有显著的优势。研究了单金属金、银和钯纳米粒子、双金属 Ag-Pd 和 Au-Pd 纳米粒子以及各种贵金属阳离子比例的三金属 Ag-Au-Pd 纳米粒子的形成，并评估了它们在基于监测同步荧光光谱（SFS）的非酶葡萄糖传感中的生物催化活性。在这些纳米粒子中，Au:Pd 比例为 80:20 的 Au-Pd 显示出对葡萄糖传感的优异催化活性。这些纳米粒子还可以与 Nafion 均匀化，以增强共振瑞利散射（RRS）信号。在这项研究中，报告了贵金属纳米粒子以及双金属和三金属纳米粒子的结构表征及其在非酶葡萄糖传感中的应用。
